Journal Article

DKFZ-2017-00817

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The impact of allogeneic stem cell transplantation on the natural course of poor-risk chronic lymphocytic leukemia as defined by the EBMT consensus criteria: a retrospective donor versus no donor comparison.

Herth, I. ; Dietrich, S.Extern* ; Benner, A.DKFZ* ; Hegenbart, U. ; Rieger, M. ; Stadtherr, P. ; Bondong, A. ; Tran, T. H. ; Weide, R. ; Hensel, M. ; Knauf, W. ; Franz-Werner, J. ; Welslau, M. ; Procaccianti, M. ; Görner, M. ; Meissner, J. ; Luft, T. ; Schönland, S. ; Witzens-Harig, M. ; Zenz, T.DKFZ* ; Ho, A. D. ; Dreger, P.

2014
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/annonc/mdt511

Abstract: In a single-center retrospective donor versus no-donor comparison, we investigated if allogeneic stem cell transplantation (alloSCT) can improve the dismal course of poor-risk chronic lymphocytic leukemia (CLL).All patients with CLL who were referred for evaluation of alloSCT within a 7-year time frame and had a donor search indication according to the EBMT criteria or because of Richter's transformation were included. Patients for whom a matched donor could be found within 3 months (matches) were compared with patients without such a donor (controls). Primary end point was overall survival measured from the 3-month landmark after search initiation.Of 105 patients with donor search, 97 (matches 83; controls 14) were assessable at the 3-month landmark. Matches and controls were comparable for age, gender, time from diagnosis, number of previous regimens, and remission status. Disregarding if alloSCT was actually carried out or not, survival from the 3-month landmark was significantly better in matches versus controls [hazard ratio 0.38, 95% confidence interval (CI) 0.17-0.85; P = 0.014]. The survival benefit of matches remained significant on multivariate analysis.This study provides first comparative evidence that alloSCT may have the potential to improve the natural course of poor-risk CLL as defined by the EBMT criteria.

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Contributing Institute(s):

1. Biostatistik (C060)
2. Translationale Onkologie (G100)

Research Program(s):

1. 317 - Translational cancer research (POF3-317) (POF3-317)

Appears in the scientific report 2014

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Database coverage:
; Allianz-Lizenz / DFG ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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