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000125773 037__ $$aDKFZ-2017-01899
000125773 041__ $$aeng
000125773 082__ $$a610
000125773 1001_ $$aEngel, Isaac$$b0
000125773 245__ $$aInnate-like functions of natural killer T cell subsets result from highly divergent gene programs.
000125773 260__ $$aNew York, NY$$bNature America Inc.$$c2016
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000125773 520__ $$aNatural killer T cells (NKT cells) have stimulatory or inhibitory effects on the immune response that can be attributed in part to the existence of functional subsets of NKT cells. These subsets have been characterized only on the basis of the differential expression of a few transcription factors and cell-surface molecules. Here we have analyzed purified populations of thymic NKT cell subsets at both the transcriptomic level and epigenomic level and by single-cell RNA sequencing. Our data indicated that despite their similar antigen specificity, the functional NKT cell subsets were highly divergent populations with many gene-expression and epigenetic differences. Therefore, the thymus imprints distinct gene programs on subsets of innate-like NKT cells that probably impart differences in proliferative capacity, homing, and effector functions.
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000125773 650_7 $$2NLM Chemicals$$aAntigens, CD1d
000125773 650_7 $$2NLM Chemicals$$aCd1d1 protein, mouse
000125773 650_7 $$0EC 1.14.11.-$$2NLM Chemicals$$aJumonji Domain-Containing Histone Demethylases
000125773 650_7 $$0EC 1.5.-$$2NLM Chemicals$$aKdm6b protein, mouse
000125773 7001_ $$00000-0002-8164-6852$$aSeumois, Grégory$$b1
000125773 7001_ $$0P:(DE-He78)082dd3179733e3e716a58eb90f418a78$$aChavez-Kuss, Lukas$$b2$$udkfz
000125773 7001_ $$aSamaniego-Castruita, Daniela$$b3
000125773 7001_ $$aWhite, Brandie$$b4
000125773 7001_ $$aChawla, Ashu$$b5
000125773 7001_ $$aMock, Dennis$$b6
000125773 7001_ $$aVijayanand, Pandurangan$$b7
000125773 7001_ $$aKronenberg, Mitchell$$b8
000125773 773__ $$0PERI:(DE-600)2026412-4$$a10.1038/ni.3437$$gVol. 17, no. 6, p. 728 - 739$$n6$$p728 - 739$$tNature immunology$$v17$$x1529-2916$$y2016
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000125773 9141_ $$y2016
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