Journal Article

DKFZ-2017-01899

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Innate-like functions of natural killer T cell subsets result from highly divergent gene programs.

Engel, I. ; Seumois, G. ; Chavez-Kuss, L.DKFZ* ; Samaniego-Castruita, D. ; White, B. ; Chawla, A. ; Mock, D. ; Vijayanand, P. ; Kronenberg, M.

2016
Nature America Inc. New York, NY

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Please use a persistent id in citations: doi:10.1038/ni.3437

Abstract: Natural killer T cells (NKT cells) have stimulatory or inhibitory effects on the immune response that can be attributed in part to the existence of functional subsets of NKT cells. These subsets have been characterized only on the basis of the differential expression of a few transcription factors and cell-surface molecules. Here we have analyzed purified populations of thymic NKT cell subsets at both the transcriptomic level and epigenomic level and by single-cell RNA sequencing. Our data indicated that despite their similar antigen specificity, the functional NKT cell subsets were highly divergent populations with many gene-expression and epigenetic differences. Therefore, the thymus imprints distinct gene programs on subsets of innate-like NKT cells that probably impart differences in proliferative capacity, homing, and effector functions.

Keyword(s): Antigens, CD1d ; Cd1d1 protein, mouse ; Jumonji Domain-Containing Histone Demethylases ; Kdm6b protein, mouse

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Contributing Institute(s):

1. Pädiatrische Neuroonkologie (B062)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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