TY  - JOUR
AU  - Engel, Isaac
AU  - Seumois, Grégory
AU  - Chavez-Kuss, Lukas
AU  - Samaniego-Castruita, Daniela
AU  - White, Brandie
AU  - Chawla, Ashu
AU  - Mock, Dennis
AU  - Vijayanand, Pandurangan
AU  - Kronenberg, Mitchell
TI  - Innate-like functions of natural killer T cell subsets result from highly divergent gene programs.
JO  - Nature immunology
VL  - 17
IS  - 6
SN  - 1529-2916
CY  - New York, NY
PB  - Nature America Inc.
M1  - DKFZ-2017-01899
SP  - 728 - 739
PY  - 2016
AB  - Natural killer T cells (NKT cells) have stimulatory or inhibitory effects on the immune response that can be attributed in part to the existence of functional subsets of NKT cells. These subsets have been characterized only on the basis of the differential expression of a few transcription factors and cell-surface molecules. Here we have analyzed purified populations of thymic NKT cell subsets at both the transcriptomic level and epigenomic level and by single-cell RNA sequencing. Our data indicated that despite their similar antigen specificity, the functional NKT cell subsets were highly divergent populations with many gene-expression and epigenetic differences. Therefore, the thymus imprints distinct gene programs on subsets of innate-like NKT cells that probably impart differences in proliferative capacity, homing, and effector functions.
KW  - Antigens, CD1d (NLM Chemicals)
KW  - Cd1d1 protein, mouse (NLM Chemicals)
KW  - Jumonji Domain-Containing Histone Demethylases (NLM Chemicals)
KW  - Kdm6b protein, mouse (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27089380
C2  - pmc:PMC4944658
DO  - DOI:10.1038/ni.3437
UR  - https://inrepo02.dkfz.de/record/125773
ER  -