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| Home > Publications database > Innate-like functions of natural killer T cell subsets result from highly divergent gene programs. > print |
| 001 | 125773 | ||
| 005 | 20240228143331.0 | ||
| 024 | 7 | _ | |a 10.1038/ni.3437 |2 doi |
| 024 | 7 | _ | |a pmid:27089380 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4944658 |2 pmc |
| 024 | 7 | _ | |a 1529-2908 |2 ISSN |
| 024 | 7 | _ | |a 1529-2916 |2 ISSN |
| 024 | 7 | _ | |a altmetric:6783157 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-01899 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Engel, Isaac |b 0 |
| 245 | _ | _ | |a Innate-like functions of natural killer T cell subsets result from highly divergent gene programs. |
| 260 | _ | _ | |a New York, NY |c 2016 |b Nature America Inc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521724102_15724 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Natural killer T cells (NKT cells) have stimulatory or inhibitory effects on the immune response that can be attributed in part to the existence of functional subsets of NKT cells. These subsets have been characterized only on the basis of the differential expression of a few transcription factors and cell-surface molecules. Here we have analyzed purified populations of thymic NKT cell subsets at both the transcriptomic level and epigenomic level and by single-cell RNA sequencing. Our data indicated that despite their similar antigen specificity, the functional NKT cell subsets were highly divergent populations with many gene-expression and epigenetic differences. Therefore, the thymus imprints distinct gene programs on subsets of innate-like NKT cells that probably impart differences in proliferative capacity, homing, and effector functions. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Antigens, CD1d |2 NLM Chemicals |
| 650 | _ | 7 | |a Cd1d1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Jumonji Domain-Containing Histone Demethylases |0 EC 1.14.11.- |2 NLM Chemicals |
| 650 | _ | 7 | |a Kdm6b protein, mouse |0 EC 1.5.- |2 NLM Chemicals |
| 700 | 1 | _ | |a Seumois, Grégory |0 0000-0002-8164-6852 |b 1 |
| 700 | 1 | _ | |a Chavez-Kuss, Lukas |0 P:(DE-He78)082dd3179733e3e716a58eb90f418a78 |b 2 |u dkfz |
| 700 | 1 | _ | |a Samaniego-Castruita, Daniela |b 3 |
| 700 | 1 | _ | |a White, Brandie |b 4 |
| 700 | 1 | _ | |a Chawla, Ashu |b 5 |
| 700 | 1 | _ | |a Mock, Dennis |b 6 |
| 700 | 1 | _ | |a Vijayanand, Pandurangan |b 7 |
| 700 | 1 | _ | |a Kronenberg, Mitchell |b 8 |
| 773 | _ | _ | |a 10.1038/ni.3437 |g Vol. 17, no. 6, p. 728 - 739 |0 PERI:(DE-600)2026412-4 |n 6 |p 728 - 739 |t Nature immunology |v 17 |y 2016 |x 1529-2916 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:125773 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)082dd3179733e3e716a58eb90f418a78 |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2016 |
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