%0 Journal Article
%A Halama, Niels
%A Zoernig, Inka
%A Berthel, Anna
%A Kahlert, Christoph
%A Klupp, Fee
%A Suarez-Carmona, Meggy
%A Suetterlin, Thomas
%A Brand, Karsten
%A Krauss, Juergen
%A Lasitschka, Felix
%A Lerchl, Tina
%A Luckner-Minden, Claudia
%A Ulrich, Alexis
%A Koch, Moritz
%A Weitz, Juergen
%A Schneider, Martin
%A Buechler, Markus W
%A Zitvogel, Laurence
%A Herrmann, Thomas
%A Benner, Axel
%A Kunz, Christina
%A Lücke, Stephan
%A Springfeld, Christoph
%A Grabe, Niels
%A Falk, Christine S
%A Jäger, Dirk
%T Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients.
%J Cancer cell
%V 29
%N 4
%@ 1535-6108
%C Cambridge, Mass.
%I Cell Press
%M DKFZ-2017-02077
%P 587 - 601
%D 2016
%X The immune response influences the clinical course of colorectal cancer (CRC). Analyzing the invasive margin of human CRC liver metastases, we identified a mechanism of immune cell exploitation by tumor cells. While two distinct subsets of myeloid cells induce an influx of T cells into the invasive margin via CXCL9/CXCL10, CCL5 is produced by these T cells and stimulates pro-tumoral effects via CCR5. CCR5 blockade in patient-derived functional in vitro organotypic culture models showed a macrophage repolarization with anti-tumoral effects. These anti-tumoral effects were then confirmed in a phase I trial with a CCR5 antagonist in patients with liver metastases of advanced refractory CRC. Mitigation of tumor-promoting inflammation within the tumor tissue and objective tumor responses in CRC were observed.
%K CCL5 protein, human (NLM Chemicals)
%K CCR5 protein, human (NLM Chemicals)
%K Chemokine CCL5 (NLM Chemicals)
%K Chemokines (NLM Chemicals)
%K Cyclohexanes (NLM Chemicals)
%K Interferon-alpha (NLM Chemicals)
%K Neoplasm Proteins (NLM Chemicals)
%K Phenylurea Compounds (NLM Chemicals)
%K Pyridines (NLM Chemicals)
%K Receptors, CCR5 (NLM Chemicals)
%K STAT3 Transcription Factor (NLM Chemicals)
%K STAT3 protein, human (NLM Chemicals)
%K Triazoles (NLM Chemicals)
%K Clodronic Acid (NLM Chemicals)
%K regorafenib (NLM Chemicals)
%K maraviroc (NLM Chemicals)
%K NG-Nitroarginine Methyl Ester (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:27070705
%R 10.1016/j.ccell.2016.03.005
%U https://inrepo02.dkfz.de/record/125953