Journal Article

DKFZ-2017-02077

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients.

Halama, N. ; Zoernig, I. ; Berthel, A. ; Kahlert, C. ; Klupp, F. ; Suarez-Carmona, M. ; Suetterlin, T. ; Brand, K. ; Krauss, J. ; Lasitschka, F. ; Lerchl, T. ; Luckner-Minden, C. ; Ulrich, A. ; Koch, M. ; Weitz, J. ; Schneider, M. ; Buechler, M. W. ; Zitvogel, L. ; Herrmann, T. ; Benner, A.DKFZ* ; Kunz, C.DKFZ* ; Lücke, S.DKFZ* ; Springfeld, C. ; Grabe, N. ; Falk, C. S. ; Jäger, D. (Last author)DKFZ*

2016
Cell Press Cambridge, Mass.

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.ccell.2016.03.005

Abstract: The immune response influences the clinical course of colorectal cancer (CRC). Analyzing the invasive margin of human CRC liver metastases, we identified a mechanism of immune cell exploitation by tumor cells. While two distinct subsets of myeloid cells induce an influx of T cells into the invasive margin via CXCL9/CXCL10, CCL5 is produced by these T cells and stimulates pro-tumoral effects via CCR5. CCR5 blockade in patient-derived functional in vitro organotypic culture models showed a macrophage repolarization with anti-tumoral effects. These anti-tumoral effects were then confirmed in a phase I trial with a CCR5 antagonist in patients with liver metastases of advanced refractory CRC. Mitigation of tumor-promoting inflammation within the tumor tissue and objective tumor responses in CRC were observed.

Keyword(s): CCL5 protein, human ; CCR5 protein, human ; Chemokine CCL5 ; Chemokines ; Cyclohexanes ; Interferon-alpha ; Neoplasm Proteins ; Phenylurea Compounds ; Pyridines ; Receptors, CCR5 ; STAT3 Transcription Factor ; STAT3 protein, human ; Triazoles ; Clodronic Acid ; regorafenib ; maraviroc ; NG-Nitroarginine Methyl Ester

---

Contributing Institute(s):

1. Angewandte Tumor-Immunität (D120)
2. Biostatistik (C060)
3. Geschäftsstelle (G010)

Research Program(s):

1. 314 - Tumor immunology (POF3-314) (POF3-314)

Appears in the scientific report 2016

---

Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 20 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

---