TY  - JOUR
AU  - Halama, Niels
AU  - Zoernig, Inka
AU  - Berthel, Anna
AU  - Kahlert, Christoph
AU  - Klupp, Fee
AU  - Suarez-Carmona, Meggy
AU  - Suetterlin, Thomas
AU  - Brand, Karsten
AU  - Krauss, Juergen
AU  - Lasitschka, Felix
AU  - Lerchl, Tina
AU  - Luckner-Minden, Claudia
AU  - Ulrich, Alexis
AU  - Koch, Moritz
AU  - Weitz, Juergen
AU  - Schneider, Martin
AU  - Buechler, Markus W
AU  - Zitvogel, Laurence
AU  - Herrmann, Thomas
AU  - Benner, Axel
AU  - Kunz, Christina
AU  - Lücke, Stephan
AU  - Springfeld, Christoph
AU  - Grabe, Niels
AU  - Falk, Christine S
AU  - Jäger, Dirk
TI  - Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients.
JO  - Cancer cell
VL  - 29
IS  - 4
SN  - 1535-6108
CY  - Cambridge, Mass.
PB  - Cell Press
M1  - DKFZ-2017-02077
SP  - 587 - 601
PY  - 2016
AB  - The immune response influences the clinical course of colorectal cancer (CRC). Analyzing the invasive margin of human CRC liver metastases, we identified a mechanism of immune cell exploitation by tumor cells. While two distinct subsets of myeloid cells induce an influx of T cells into the invasive margin via CXCL9/CXCL10, CCL5 is produced by these T cells and stimulates pro-tumoral effects via CCR5. CCR5 blockade in patient-derived functional in vitro organotypic culture models showed a macrophage repolarization with anti-tumoral effects. These anti-tumoral effects were then confirmed in a phase I trial with a CCR5 antagonist in patients with liver metastases of advanced refractory CRC. Mitigation of tumor-promoting inflammation within the tumor tissue and objective tumor responses in CRC were observed.
KW  - CCL5 protein, human (NLM Chemicals)
KW  - CCR5 protein, human (NLM Chemicals)
KW  - Chemokine CCL5 (NLM Chemicals)
KW  - Chemokines (NLM Chemicals)
KW  - Cyclohexanes (NLM Chemicals)
KW  - Interferon-alpha (NLM Chemicals)
KW  - Neoplasm Proteins (NLM Chemicals)
KW  - Phenylurea Compounds (NLM Chemicals)
KW  - Pyridines (NLM Chemicals)
KW  - Receptors, CCR5 (NLM Chemicals)
KW  - STAT3 Transcription Factor (NLM Chemicals)
KW  - STAT3 protein, human (NLM Chemicals)
KW  - Triazoles (NLM Chemicals)
KW  - Clodronic Acid (NLM Chemicals)
KW  - regorafenib (NLM Chemicals)
KW  - maraviroc (NLM Chemicals)
KW  - NG-Nitroarginine Methyl Ester (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27070705
DO  - DOI:10.1016/j.ccell.2016.03.005
UR  - https://inrepo02.dkfz.de/record/125953
ER  -