Journal Article

DKFZ-2017-02087

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Amelioration of sepsis by TIE2 activation-induced vascular protection.

Han, S. ; Lee, S.-J. ; Kim, K. E. ; Lee, H. S. ; Oh, N. ; Park, I. ; Ko, E. ; Oh, S. J. ; Lee, Y.-S. ; Kim, D. ; Lee, S. ; Lee, D. H. ; Lee, K.-H. ; Chae, S. Y. ; Lee, J.-H. ; Kim, S.-J. ; Kim, H.-C. ; Kim, S. ; Kim, S. H. ; Kim, C. ; Nakaoka, Y. ; He, Y. ; Augustin, H.DKFZ* ; Hu, J.DKFZ* ; Song, P. H. ; Kim, Y.-I. ; Kim, P. ; Kim, I. ; Koh, G. Y.

2016
AAAS Washington, DC

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Please use a persistent id in citations: doi:10.1126/scitranslmed.aad9260

Abstract: Protection of endothelial integrity has been recognized as a frontline approach to alleviating sepsis progression, yet no effective agent for preserving endothelial integrity is available. Using an unusual anti-angiopoietin 2 (ANG2) antibody, ABTAA (ANG2-binding and TIE2-activating antibody), we show that activation of the endothelial receptor TIE2 protects the vasculature from septic damage and provides survival benefit in three sepsis mouse models. Upon binding to ANG2, ABTAA triggers clustering of ANG2, assembling an ABTAA/ANG2 complex that can subsequently bind and activate TIE2. Compared with a conventional ANG2-blocking antibody, ABTAA was highly effective in augmenting survival from sepsis by strengthening the endothelial glycocalyx, reducing cytokine storms, vascular leakage, and rarefaction, and mitigating organ damage. Together, our data advance the role of TIE2 activation in ameliorating sepsis progression and open a potential therapeutic avenue for sepsis to address the lack of sepsis-specific treatment.

Note: DKFZ-ZMBH-Allianz

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Contributing Institute(s):

1. Vaskuläre Onkologie und Metastasierung (A190)

Research Program(s):

1. 321 - Basic Concepts (POF3-321) (POF3-321)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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