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000126030 0247_ $$2ISSN$$a1868-8551
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000126030 1001_ $$0P:(DE-HGF)0$$aAleksandrowicz, Ewa$$b0$$eFirst author
000126030 245__ $$aEthical euthanasia and short-term anesthesia of the chick embryo.
000126030 260__ $$aHeidelberg$$bALTEX Edition$$c2015
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000126030 520__ $$aFertilized chicken eggs are suggested as an alternative to mammalian models. The chorioallantoic membrane (CAM) of the chick embryo is widely used for examination of angiogenesis, xenotransplants and for virus production. Unfortunately, it is mostly not taken into account, that the chick embryo's ability to experience pain starts to develop at day 7 of breeding. In our view, this model is only in accordance with the 3 R principles, if an appropriate anesthesia of the chick embryo in potentially painful procedures is provided. Although many experimental approaches are performed on the none-innervated CAM, the euthanasia of the embryo strongly requires a more human technique than the usually used freezing at -20°C, decapitation or in ovo fixation with paraformaldehyde without prior anesthesia. However, protocols regarding feasible and ethical methods for anesthesia and euthanasia of avian embryos are currently not available. Therefore, we established an easy and reliable method for the euthanasia and short-term anesthesia of the chick embryo.
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000126030 7001_ $$0P:(DE-HGF)0$$aHerr, Ingrid$$b1$$eLast author
000126030 773__ $$0PERI:(DE-600)2584909-8$$a10.14573/altex.1410031$$gVol. 32, no. 2$$n2$$p143-147$$tAlternatives to animal experimentation$$v32$$x1868-596X$$y2015
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