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000126715 0247_ $$2doi$$a10.1038/bjc.2013.745
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000126715 0247_ $$2ISSN$$a1532-1827
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000126715 037__ $$aDKFZ-2017-02743
000126715 041__ $$aeng
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000126715 1001_ $$aKahlert, C.$$b0
000126715 245__ $$aTumour-site-dependent expression profile of angiogenic factors in tumour-associated stroma of primary colorectal cancer and metastases.
000126715 260__ $$aEdinburgh$$bNature Publ. Group$$c2014
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000126715 520__ $$aTumour-associated stroma has a critical role in tumour proliferation. Our aim was to determine a specific protein expression profile of stromal angiogenic cytokines and matrix metalloproteinases (MMPs) to identify potential biomarkers or new therapy targets.Frozen tissue of primary colorectal cancer (n=25), liver (n=25) and lung metastases (n=23) was laser-microdissected to obtain tumour epithelial cells and adjacent tumour-associated stroma. Protein expression of nine angiogenic cytokines and eight MMPs was analysed using a multiplex-based protein assay.We found a differential expression of several MMPs and angiogenic cytokines in tumour cells compared with adjacent tumour stroma. Cluster analysis displayed a tumour-site-dependent stromal expression of MMPs and angiogenic cytokines. Univariate analysis identified stromal MMP-2 and MMP-3 in primary colorectal cancer, stromal MMP-1, -2, -3 and Angiopoietin-2 in lung metastases and stromal MMP-12 and VEGF in liver metastases as prognostic markers (P>0.05, respectively). Furthermore, stroma-derived Angiopoietin-2 proved to be an independent prognostic marker in colorectal lung metastases.Expression of MMPs and angiogenic cytokines in tumour cells and adjacent tumour stroma is dependent on the tumour site. Stroma-derived MMPs and angiogenic cytokines may be useful prognostic biomarkers. These data can be helpful to identify new agents for a targeted therapy in patients with colorectal cancer.
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000126715 650_7 $$2NLM Chemicals$$aAngiogenesis Inducing Agents
000126715 650_7 $$2NLM Chemicals$$aAngiopoietin-2
000126715 650_7 $$2NLM Chemicals$$aBiomarkers, Tumor
000126715 650_7 $$2NLM Chemicals$$aCytokines
000126715 650_7 $$2NLM Chemicals$$aVEGFA protein, human
000126715 650_7 $$2NLM Chemicals$$aVascular Endothelial Growth Factor A
000126715 650_7 $$0EC 3.4.24.-$$2NLM Chemicals$$aMatrix Metalloproteinases
000126715 7001_ $$aPecqueux, M.$$b1
000126715 7001_ $$0P:(DE-He78)0a4053be7ffd6aa9bef69de28753a601$$aHalama, Niels$$b2$$udkfz
000126715 7001_ $$aDienemann, H.$$b3
000126715 7001_ $$aMuley, T.$$b4
000126715 7001_ $$aPfannschmidt, J.$$b5
000126715 7001_ $$aLasitschka, F.$$b6
000126715 7001_ $$aKlupp, F.$$b7
000126715 7001_ $$0P:(DE-HGF)0$$aSchmidt, T.$$b8
000126715 7001_ $$aRahbari, N.$$b9
000126715 7001_ $$aReissfelder, C.$$b10
000126715 7001_ $$0P:(DE-He78)a9f6104e5c2c26345dcb242e6bdcb2b2$$aKunz, Christina$$b11$$udkfz
000126715 7001_ $$0P:(DE-He78)e15dfa1260625c69d6690a197392a994$$aBenner, Axel$$b12$$udkfz
000126715 7001_ $$aFalk, C.$$b13
000126715 7001_ $$aWeitz, J.$$b14
000126715 7001_ $$0P:(DE-HGF)0$$aKoch, M.$$b15
000126715 773__ $$0PERI:(DE-600)2002452-6$$a10.1038/bjc.2013.745$$gVol. 110, no. 2, p. 441 - 449$$n2$$p441 - 449$$tBritish journal of cancer$$v110$$x1532-1827$$y2014
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