Home > Publications database > Tumour-site-dependent expression profile of angiogenic factors in tumour-associated stroma of primary colorectal cancer and metastases. > print

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024 7 _ |a 10.1038/bjc.2013.745
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024 7 _ |a 1532-1827
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037 _ _ |a DKFZ-2017-02743
041 _ _ |a eng
082 _ _ |a 610
100 1 _ |a Kahlert, C.
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245 _ _ |a Tumour-site-dependent expression profile of angiogenic factors in tumour-associated stroma of primary colorectal cancer and metastases.
260 _ _ |a Edinburgh
|c 2014
|b Nature Publ. Group
336 7 _ |a article
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520 _ _ |a Tumour-associated stroma has a critical role in tumour proliferation. Our aim was to determine a specific protein expression profile of stromal angiogenic cytokines and matrix metalloproteinases (MMPs) to identify potential biomarkers or new therapy targets.Frozen tissue of primary colorectal cancer (n=25), liver (n=25) and lung metastases (n=23) was laser-microdissected to obtain tumour epithelial cells and adjacent tumour-associated stroma. Protein expression of nine angiogenic cytokines and eight MMPs was analysed using a multiplex-based protein assay.We found a differential expression of several MMPs and angiogenic cytokines in tumour cells compared with adjacent tumour stroma. Cluster analysis displayed a tumour-site-dependent stromal expression of MMPs and angiogenic cytokines. Univariate analysis identified stromal MMP-2 and MMP-3 in primary colorectal cancer, stromal MMP-1, -2, -3 and Angiopoietin-2 in lung metastases and stromal MMP-12 and VEGF in liver metastases as prognostic markers (P>0.05, respectively). Furthermore, stroma-derived Angiopoietin-2 proved to be an independent prognostic marker in colorectal lung metastases.Expression of MMPs and angiogenic cytokines in tumour cells and adjacent tumour stroma is dependent on the tumour site. Stroma-derived MMPs and angiogenic cytokines may be useful prognostic biomarkers. These data can be helpful to identify new agents for a targeted therapy in patients with colorectal cancer.
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650 _ 7 |a Angiogenesis Inducing Agents
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650 _ 7 |a Angiopoietin-2
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650 _ 7 |a Biomarkers, Tumor
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650 _ 7 |a Cytokines
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650 _ 7 |a VEGFA protein, human
|2 NLM Chemicals
650 _ 7 |a Vascular Endothelial Growth Factor A
|2 NLM Chemicals
650 _ 7 |a Matrix Metalloproteinases
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700 1 _ |a Pecqueux, M.
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700 1 _ |a Halama, Niels
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700 1 _ |a Dienemann, H.
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700 1 _ |a Muley, T.
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700 1 _ |a Pfannschmidt, J.
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700 1 _ |a Lasitschka, F.
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700 1 _ |a Klupp, F.
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700 1 _ |a Schmidt, T.
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700 1 _ |a Rahbari, N.
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700 1 _ |a Reissfelder, C.
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700 1 _ |a Kunz, Christina
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700 1 _ |a Benner, Axel
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700 1 _ |a Falk, C.
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700 1 _ |a Weitz, J.
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700 1 _ |a Koch, M.
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773 _ _ |a 10.1038/bjc.2013.745
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