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000126894 041__ $$aeng
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000126894 1001_ $$aKöster, Sarah$$b0
000126894 245__ $$aIntermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks.
000126894 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2015
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000126894 520__ $$aIntermediate filament proteins form filaments, fibers and networks both in the cytoplasm and the nucleus of metazoan cells. Their general structural building plan accommodates highly varying amino acid sequences to yield extended dimeric α-helical coiled coils of highly conserved design. These rod particles are the basic building blocks of intrinsically flexible, filamentous structures that are able to resist high mechanical stresses, that is, bending and stretching to a considerable degree, both in vitro and in the cell. Biophysical and computer modeling studies are beginning to unfold detailed structural and mechanical insights into these major supramolecular assemblies of cell architecture, not only in the test tube but also in the cellular and tissue context.
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000126894 650_7 $$2NLM Chemicals$$aAmino Acids
000126894 7001_ $$aWeitz, David A$$b1
000126894 7001_ $$aGoldman, Robert D$$b2
000126894 7001_ $$aAebi, Ueli$$b3
000126894 7001_ $$0P:(DE-He78)7892a89fee19b8e3912c7423d660765d$$aHerrmann, Harald$$b4$$udkfz
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