Journal Article

DKFZ-2017-02922

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks.

Köster, S. ; Weitz, D. A. ; Goldman, R. D. ; Aebi, U. ; Herrmann, H.DKFZ*

2015
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.ceb.2015.01.001

Abstract: Intermediate filament proteins form filaments, fibers and networks both in the cytoplasm and the nucleus of metazoan cells. Their general structural building plan accommodates highly varying amino acid sequences to yield extended dimeric α-helical coiled coils of highly conserved design. These rod particles are the basic building blocks of intrinsically flexible, filamentous structures that are able to resist high mechanical stresses, that is, bending and stretching to a considerable degree, both in vitro and in the cell. Biophysical and computer modeling studies are beginning to unfold detailed structural and mechanical insights into these major supramolecular assemblies of cell architecture, not only in the test tube but also in the cellular and tissue context.

Keyword(s): Amino Acids

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Contributing Institute(s):

1. Funktionelle Zellarchitektur (B065)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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