%0 Journal Article
%A Lu, Kun-Hui
%A Tounsi, Amel
%A Shridhar, Naveen
%A Küblbeck, Günter
%A Klevenz, Alexandra
%A Prokosch, Sandra
%A Bald, Tobias
%A Tüting, Thomas
%A Arnold, Bernd
%T Dickkopf-3 Contributes to the Regulation of Anti-Tumor Immune Responses by Mesenchymal Stem Cells.
%J Frontiers in immunology
%V 6
%@ 1664-3224
%C Lausanne
%I Frontiers Media
%M DKFZ-2017-03062
%P 645
%D 2015
%X Mesenchymal stem cells (MSCs) are known to limit immune responses in vivo by multiple soluble factors. Dickkopf-3 (DKK3), a secreted glycoprotein, has recently been identified as a novel immune modulator. Since DKK3 has been reported to be produced by MSCs, we investigated whether DKK3 contributes to the immune suppression of anti-tumor responses by MSCs. Whereas wild-type MSCs inhibited immune responses against two different transplantation tumors, DKK3-deficient MSCs did not affect the rejection process. Increased CD8(+) T cell and reduced M2-type macrophages infiltration was observed in tumors inoculated together with DKK3-deficient MSCs. Thus, DKK3 could alter the composition of the tumor stroma, thereby supporting the MSCs-mediated suppression of immune responses against these tumor transplants.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26734010
%2 pmc:PMC4689786
%R 10.3389/fimmu.2015.00645
%U https://inrepo02.dkfz.de/record/127036