Journal Article

DKFZ-2017-03062

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dickkopf-3 Contributes to the Regulation of Anti-Tumor Immune Responses by Mesenchymal Stem Cells.

Lu, K.-H. (First author)DKFZ* ; Tounsi, A.DKFZ* ; Shridhar, N. ; Küblbeck, G.DKFZ* ; Klevenz, A.DKFZ* ; Prokosch, S.DKFZ* ; Bald, T. ; Tüting, T. ; Arnold, B. (Last author)DKFZ*

2015
Frontiers Media Lausanne

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Please use a persistent id in citations: doi:10.3389/fimmu.2015.00645

Abstract: Mesenchymal stem cells (MSCs) are known to limit immune responses in vivo by multiple soluble factors. Dickkopf-3 (DKK3), a secreted glycoprotein, has recently been identified as a novel immune modulator. Since DKK3 has been reported to be produced by MSCs, we investigated whether DKK3 contributes to the immune suppression of anti-tumor responses by MSCs. Whereas wild-type MSCs inhibited immune responses against two different transplantation tumors, DKK3-deficient MSCs did not affect the rejection process. Increased CD8(+) T cell and reduced M2-type macrophages infiltration was observed in tumors inoculated together with DKK3-deficient MSCs. Thus, DKK3 could alter the composition of the tumor stroma, thereby supporting the MSCs-mediated suppression of immune responses against these tumor transplants.

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Contributing Institute(s):

1. Molekulare Immunologie (D050)

Research Program(s):

1. 314 - Tumor immunology (POF3-314) (POF3-314)

Appears in the scientific report 2015

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Database coverage:
; ; ; DOAJ Seal ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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