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000127036 1001_ $$0P:(DE-HGF)0$$aLu, Kun-Hui$$b0$$eFirst author
000127036 245__ $$aDickkopf-3 Contributes to the Regulation of Anti-Tumor Immune Responses by Mesenchymal Stem Cells.
000127036 260__ $$aLausanne$$bFrontiers Media$$c2015
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000127036 520__ $$aMesenchymal stem cells (MSCs) are known to limit immune responses in vivo by multiple soluble factors. Dickkopf-3 (DKK3), a secreted glycoprotein, has recently been identified as a novel immune modulator. Since DKK3 has been reported to be produced by MSCs, we investigated whether DKK3 contributes to the immune suppression of anti-tumor responses by MSCs. Whereas wild-type MSCs inhibited immune responses against two different transplantation tumors, DKK3-deficient MSCs did not affect the rejection process. Increased CD8(+) T cell and reduced M2-type macrophages infiltration was observed in tumors inoculated together with DKK3-deficient MSCs. Thus, DKK3 could alter the composition of the tumor stroma, thereby supporting the MSCs-mediated suppression of immune responses against these tumor transplants.
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000127036 7001_ $$0P:(DE-HGF)0$$aTounsi, Amel$$b1
000127036 7001_ $$aShridhar, Naveen$$b2
000127036 7001_ $$0P:(DE-He78)b8759faaf3e907bcd8b6a34983994a3c$$aKüblbeck, Günter$$b3$$udkfz
000127036 7001_ $$0P:(DE-He78)de65818249a2e18aa4309f229917f4a4$$aKlevenz, Alexandra$$b4$$udkfz
000127036 7001_ $$0P:(DE-He78)3c6157a315192b4a95e0138399b89da9$$aProkosch, Sandra$$b5$$udkfz
000127036 7001_ $$aBald, Tobias$$b6
000127036 7001_ $$aTüting, Thomas$$b7
000127036 7001_ $$0P:(DE-He78)554abc2af2666cc3421cc0d7f6e7b6de$$aArnold, Bernd$$b8$$eLast author$$udkfz
000127036 773__ $$0PERI:(DE-600)2606827-8$$a10.3389/fimmu.2015.00645$$gVol. 6$$p645$$tFrontiers in immunology$$v6$$x1664-3224$$y2015
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