TY  - JOUR
AU  - Lu, Kun-Hui
AU  - Tounsi, Amel
AU  - Shridhar, Naveen
AU  - Küblbeck, Günter
AU  - Klevenz, Alexandra
AU  - Prokosch, Sandra
AU  - Bald, Tobias
AU  - Tüting, Thomas
AU  - Arnold, Bernd
TI  - Dickkopf-3 Contributes to the Regulation of Anti-Tumor Immune Responses by Mesenchymal Stem Cells.
JO  - Frontiers in immunology
VL  - 6
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2017-03062
SP  - 645
PY  - 2015
AB  - Mesenchymal stem cells (MSCs) are known to limit immune responses in vivo by multiple soluble factors. Dickkopf-3 (DKK3), a secreted glycoprotein, has recently been identified as a novel immune modulator. Since DKK3 has been reported to be produced by MSCs, we investigated whether DKK3 contributes to the immune suppression of anti-tumor responses by MSCs. Whereas wild-type MSCs inhibited immune responses against two different transplantation tumors, DKK3-deficient MSCs did not affect the rejection process. Increased CD8(+) T cell and reduced M2-type macrophages infiltration was observed in tumors inoculated together with DKK3-deficient MSCs. Thus, DKK3 could alter the composition of the tumor stroma, thereby supporting the MSCs-mediated suppression of immune responses against these tumor transplants.
LB  - PUB:(DE-HGF)16
C6  - pmid:26734010
C2  - pmc:PMC4689786
DO  - DOI:10.3389/fimmu.2015.00645
UR  - https://inrepo02.dkfz.de/record/127036
ER  -