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@ARTICLE{Lu:127036,
      author       = {K.-H. Lu$^*$ and A. Tounsi$^*$ and N. Shridhar and G.
                      Küblbeck$^*$ and A. Klevenz$^*$ and S. Prokosch$^*$ and T.
                      Bald and T. Tüting and B. Arnold$^*$},
      title        = {{D}ickkopf-3 {C}ontributes to the {R}egulation of
                      {A}nti-{T}umor {I}mmune {R}esponses by {M}esenchymal {S}tem
                      {C}ells.},
      journal      = {Frontiers in immunology},
      volume       = {6},
      issn         = {1664-3224},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2017-03062},
      pages        = {645},
      year         = {2015},
      abstract     = {Mesenchymal stem cells (MSCs) are known to limit immune
                      responses in vivo by multiple soluble factors. Dickkopf-3
                      (DKK3), a secreted glycoprotein, has recently been
                      identified as a novel immune modulator. Since DKK3 has been
                      reported to be produced by MSCs, we investigated whether
                      DKK3 contributes to the immune suppression of anti-tumor
                      responses by MSCs. Whereas wild-type MSCs inhibited immune
                      responses against two different transplantation tumors,
                      DKK3-deficient MSCs did not affect the rejection process.
                      Increased CD8(+) T cell and reduced M2-type macrophages
                      infiltration was observed in tumors inoculated together with
                      DKK3-deficient MSCs. Thus, DKK3 could alter the composition
                      of the tumor stroma, thereby supporting the MSCs-mediated
                      suppression of immune responses against these tumor
                      transplants.},
      cin          = {D050},
      ddc          = {610},
      cid          = {I:(DE-He78)D050-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26734010},
      pmc          = {pmc:PMC4689786},
      doi          = {10.3389/fimmu.2015.00645},
      url          = {https://inrepo02.dkfz.de/record/127036},
}