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| 001 | 127036 | ||
| 005 | 20240228140902.0 | ||
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| 041 | _ | _ | |a eng |
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| 100 | 1 | _ | |a Lu, Kun-Hui |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Dickkopf-3 Contributes to the Regulation of Anti-Tumor Immune Responses by Mesenchymal Stem Cells. |
| 260 | _ | _ | |a Lausanne |c 2015 |b Frontiers Media |
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| 520 | _ | _ | |a Mesenchymal stem cells (MSCs) are known to limit immune responses in vivo by multiple soluble factors. Dickkopf-3 (DKK3), a secreted glycoprotein, has recently been identified as a novel immune modulator. Since DKK3 has been reported to be produced by MSCs, we investigated whether DKK3 contributes to the immune suppression of anti-tumor responses by MSCs. Whereas wild-type MSCs inhibited immune responses against two different transplantation tumors, DKK3-deficient MSCs did not affect the rejection process. Increased CD8(+) T cell and reduced M2-type macrophages infiltration was observed in tumors inoculated together with DKK3-deficient MSCs. Thus, DKK3 could alter the composition of the tumor stroma, thereby supporting the MSCs-mediated suppression of immune responses against these tumor transplants. |
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| 700 | 1 | _ | |a Tounsi, Amel |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Shridhar, Naveen |b 2 |
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| 700 | 1 | _ | |a Prokosch, Sandra |0 P:(DE-He78)3c6157a315192b4a95e0138399b89da9 |b 5 |u dkfz |
| 700 | 1 | _ | |a Bald, Tobias |b 6 |
| 700 | 1 | _ | |a Tüting, Thomas |b 7 |
| 700 | 1 | _ | |a Arnold, Bernd |0 P:(DE-He78)554abc2af2666cc3421cc0d7f6e7b6de |b 8 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.3389/fimmu.2015.00645 |g Vol. 6 |0 PERI:(DE-600)2606827-8 |p 645 |t Frontiers in immunology |v 6 |y 2015 |x 1664-3224 |
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