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000127092 0247_ $$2doi$$a10.1038/jid.2015.130
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000127092 0247_ $$2ISSN$$a0022-202X
000127092 0247_ $$2ISSN$$a1523-1747
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000127092 1001_ $$0P:(DE-He78)aa3ff9fc2739d5cb7f822cbd7c1e39c9$$aMeister, Michael$$b0$$eFirst author$$udkfz
000127092 245__ $$aSelf-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T-Cell Auto-Reactivity.
000127092 260__ $$aAmsterdam$$bElsevier$$c2015
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000127092 520__ $$aKeratinocytes have a pivotal role in the regulation of immune responses, but the impact of antigen presentation by these cells is still poorly understood, particularly in a situation where the antigen will be presented only in adult life. Here, we generated a transgenic mouse model in which keratinocytes exclusively present a myelin basic protein (MBP) peptide covalently linked to the major histocompatibility complex class II β-chain, solely under inflammatory conditions. In these mice, inflammation caused by epicutaneous contact sensitizer treatment resulted in keratinocyte-mediated expansion of MBP-specific CD4(+) T cells in the skin. Moreover, repeated contact sensitizer application preceding a systemic MBP immunization reduced the reactivity of the respective CD4(+) T cells and lowered the symptoms of the resulting experimental autoimmune encephalomyelitis. This downregulation was CD4(+) T-cell-mediated and dependent on the presence of the immune modulator Dickkopf-3. Thus, presentation of a neo self-antigen by keratinocytes in the inflamed, adult skin can modulate CD4(+) T-cell auto-aggression at a distal organ.
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000127092 650_7 $$2NLM Chemicals$$a4-ethoxymethylene-2-phenyl-2-oxazoline-5-one
000127092 650_7 $$2NLM Chemicals$$aAutoantigens
000127092 650_7 $$2NLM Chemicals$$aCyclopropanes
000127092 650_7 $$2NLM Chemicals$$aDkk3 protein, mouse
000127092 650_7 $$2NLM Chemicals$$aIntercellular Signaling Peptides and Proteins
000127092 650_7 $$2NLM Chemicals$$aMyelin Basic Protein
000127092 650_7 $$2NLM Chemicals$$aOxazoles
000127092 650_7 $$0I7G14NW5EC$$2NLM Chemicals$$adiphenylcyclopropenone
000127092 7001_ $$0P:(DE-HGF)0$$aTounsi, Amel$$b1
000127092 7001_ $$aGaffal, Evelyn$$b2
000127092 7001_ $$aBald, Tobias$$b3
000127092 7001_ $$0P:(DE-HGF)0$$aPapatriantafyllou, Maria$$b4
000127092 7001_ $$0P:(DE-He78)ef1ac16ab2fde9280b9c44dfed15848f$$aLudwig, Julia$$b5$$udkfz
000127092 7001_ $$0P:(DE-He78)534f82cf960a8c8b72ecf7fe702dc42d$$aPougialis, Georg$$b6$$udkfz
000127092 7001_ $$0P:(DE-He78)89e155931400aa7bb80b79b6be41f979$$aBestvater, Felix$$b7$$udkfz
000127092 7001_ $$aKlotz, Luisa$$b8
000127092 7001_ $$0P:(DE-HGF)0$$aMoldenhauer, Gerhard$$b9
000127092 7001_ $$aTüting, Thomas$$b10
000127092 7001_ $$0P:(DE-He78)5f9901fc60b769b523d0dd8e79b3fe08$$aHämmerling, Günter$$b11$$udkfz
000127092 7001_ $$0P:(DE-He78)554abc2af2666cc3421cc0d7f6e7b6de$$aArnold, Bernd$$b12$$udkfz
000127092 7001_ $$0P:(DE-HGF)0$$aOelert, Thilo$$b13$$eLast author
000127092 773__ $$0PERI:(DE-600)2006902-9$$a10.1038/jid.2015.130$$gVol. 135, no. 8, p. 1996 - 2004$$n8$$p1996 - 2004$$tThe journal of investigative dermatology$$v135$$x0022-202X$$y2015
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