Journal Article

DKFZ-2017-03118

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Self-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T-Cell Auto-Reactivity.

Meister, M. (First author)DKFZ* ; Tounsi, A.DKFZ* ; Gaffal, E. ; Bald, T. ; Papatriantafyllou, M.DKFZ* ; Ludwig, J.DKFZ* ; Pougialis, G.DKFZ* ; Bestvater, F.DKFZ* ; Klotz, L. ; Moldenhauer, G.DKFZ* ; Tüting, T. ; Hämmerling, G.DKFZ* ; Arnold, B.DKFZ* ; Oelert, T. (Last author)DKFZ*

2015
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1038/jid.2015.130

Abstract: Keratinocytes have a pivotal role in the regulation of immune responses, but the impact of antigen presentation by these cells is still poorly understood, particularly in a situation where the antigen will be presented only in adult life. Here, we generated a transgenic mouse model in which keratinocytes exclusively present a myelin basic protein (MBP) peptide covalently linked to the major histocompatibility complex class II β-chain, solely under inflammatory conditions. In these mice, inflammation caused by epicutaneous contact sensitizer treatment resulted in keratinocyte-mediated expansion of MBP-specific CD4(+) T cells in the skin. Moreover, repeated contact sensitizer application preceding a systemic MBP immunization reduced the reactivity of the respective CD4(+) T cells and lowered the symptoms of the resulting experimental autoimmune encephalomyelitis. This downregulation was CD4(+) T-cell-mediated and dependent on the presence of the immune modulator Dickkopf-3. Thus, presentation of a neo self-antigen by keratinocytes in the inflamed, adult skin can modulate CD4(+) T-cell auto-aggression at a distal organ.

Keyword(s): 4-ethoxymethylene-2-phenyl-2-oxazoline-5-one ; Autoantigens ; Cyclopropanes ; Dkk3 protein, mouse ; Intercellular Signaling Peptides and Proteins ; Myelin Basic Protein ; Oxazoles ; diphenylcyclopropenone

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Contributing Institute(s):

1. Zelluläre und Molekulare Pathologie (G130)
2. Lichtmikroskopie (W210)
3. Molekulare Immunologie (D050)

Research Program(s):

1. 317 - Translational cancer research (POF3-317) (POF3-317)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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