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| 001 | 127092 | ||
| 005 | 20240228140906.0 | ||
| 024 | 7 | _ | |a 10.1038/jid.2015.130 |2 doi |
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| 100 | 1 | _ | |a Meister, Michael |0 P:(DE-He78)aa3ff9fc2739d5cb7f822cbd7c1e39c9 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Self-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T-Cell Auto-Reactivity. |
| 260 | _ | _ | |a Amsterdam |c 2015 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1524058158_28699 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Keratinocytes have a pivotal role in the regulation of immune responses, but the impact of antigen presentation by these cells is still poorly understood, particularly in a situation where the antigen will be presented only in adult life. Here, we generated a transgenic mouse model in which keratinocytes exclusively present a myelin basic protein (MBP) peptide covalently linked to the major histocompatibility complex class II β-chain, solely under inflammatory conditions. In these mice, inflammation caused by epicutaneous contact sensitizer treatment resulted in keratinocyte-mediated expansion of MBP-specific CD4(+) T cells in the skin. Moreover, repeated contact sensitizer application preceding a systemic MBP immunization reduced the reactivity of the respective CD4(+) T cells and lowered the symptoms of the resulting experimental autoimmune encephalomyelitis. This downregulation was CD4(+) T-cell-mediated and dependent on the presence of the immune modulator Dickkopf-3. Thus, presentation of a neo self-antigen by keratinocytes in the inflamed, adult skin can modulate CD4(+) T-cell auto-aggression at a distal organ. |
| 536 | _ | _ | |a 317 - Translational cancer research (POF3-317) |0 G:(DE-HGF)POF3-317 |c POF3-317 |f POF III |x 0 |
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| 650 | _ | 7 | |a 4-ethoxymethylene-2-phenyl-2-oxazoline-5-one |2 NLM Chemicals |
| 650 | _ | 7 | |a Autoantigens |2 NLM Chemicals |
| 650 | _ | 7 | |a Cyclopropanes |2 NLM Chemicals |
| 650 | _ | 7 | |a Dkk3 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Intercellular Signaling Peptides and Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Myelin Basic Protein |2 NLM Chemicals |
| 650 | _ | 7 | |a Oxazoles |2 NLM Chemicals |
| 650 | _ | 7 | |a diphenylcyclopropenone |0 I7G14NW5EC |2 NLM Chemicals |
| 700 | 1 | _ | |a Tounsi, Amel |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Gaffal, Evelyn |b 2 |
| 700 | 1 | _ | |a Bald, Tobias |b 3 |
| 700 | 1 | _ | |a Papatriantafyllou, Maria |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Ludwig, Julia |0 P:(DE-He78)ef1ac16ab2fde9280b9c44dfed15848f |b 5 |u dkfz |
| 700 | 1 | _ | |a Pougialis, Georg |0 P:(DE-He78)534f82cf960a8c8b72ecf7fe702dc42d |b 6 |u dkfz |
| 700 | 1 | _ | |a Bestvater, Felix |0 P:(DE-He78)89e155931400aa7bb80b79b6be41f979 |b 7 |u dkfz |
| 700 | 1 | _ | |a Klotz, Luisa |b 8 |
| 700 | 1 | _ | |a Moldenhauer, Gerhard |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Tüting, Thomas |b 10 |
| 700 | 1 | _ | |a Hämmerling, Günter |0 P:(DE-He78)5f9901fc60b769b523d0dd8e79b3fe08 |b 11 |u dkfz |
| 700 | 1 | _ | |a Arnold, Bernd |0 P:(DE-He78)554abc2af2666cc3421cc0d7f6e7b6de |b 12 |u dkfz |
| 700 | 1 | _ | |a Oelert, Thilo |0 P:(DE-HGF)0 |b 13 |e Last author |
| 773 | _ | _ | |a 10.1038/jid.2015.130 |g Vol. 135, no. 8, p. 1996 - 2004 |0 PERI:(DE-600)2006902-9 |n 8 |p 1996 - 2004 |t The journal of investigative dermatology |v 135 |y 2015 |x 0022-202X |
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