%0 Journal Article
%A Northcott, Paul A
%A Pfister, Stefan
%A Jones, David
%T Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies.
%J The lancet  / Oncology
%V 16
%N 6
%@ 1470-2045
%C London
%I The Lancet Publ. Group
%M DKFZ-2017-03253
%P e293 - e302
%D 2015
%X Arguably, nowhere has there been a greater advance in our understanding of biological mechanisms and potential translational targets during the next-generation sequencing era than in paediatric brain tumours. The so-called omics revolution, enabled by high-throughput sequencing, has empowered large consortia and independent groups alike to make major genetic discoveries, from dominant-negative histone mutations and hijacking of distal enhancer elements, to new oncogenic gene fusions and aberrantly active gene expression. Epigenetic deregulation has also been revealed as a common theme across several tumour subtypes. This Review focuses on key findings that have been transforming the landscape of paediatric neuro-oncology research and how these results are opening new avenues towards potential therapeutic translation.
%K Neoplasm Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26065614
%R 10.1016/S1470-2045(14)71206-9
%U https://inrepo02.dkfz.de/record/127228