Journal Article

DKFZ-2017-03253

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies.

Northcott, P. A. (First author)DKFZ* ; Pfister, S.DKFZ* ; Jones, D. (Last author)DKFZ*

2015
The Lancet Publ. Group London

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Please use a persistent id in citations: doi:10.1016/S1470-2045(14)71206-9

Abstract: Arguably, nowhere has there been a greater advance in our understanding of biological mechanisms and potential translational targets during the next-generation sequencing era than in paediatric brain tumours. The so-called omics revolution, enabled by high-throughput sequencing, has empowered large consortia and independent groups alike to make major genetic discoveries, from dominant-negative histone mutations and hijacking of distal enhancer elements, to new oncogenic gene fusions and aberrantly active gene expression. Epigenetic deregulation has also been revealed as a common theme across several tumour subtypes. This Review focuses on key findings that have been transforming the landscape of paediatric neuro-oncology research and how these results are opening new avenues towards potential therapeutic translation.

Keyword(s): Neoplasm Proteins

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Contributing Institute(s):

1. Pädiatrische Neuroonkologie (B062)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2015

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Database coverage:
; Current Contents - Clinical Medicine ; Ebsco Academic Search ; IF >= 25 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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