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000127228 1001_ $$0P:(DE-HGF)0$$aNorthcott, Paul A$$b0$$eFirst author
000127228 245__ $$aNext-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies.
000127228 260__ $$aLondon$$bThe Lancet Publ. Group$$c2015
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000127228 520__ $$aArguably, nowhere has there been a greater advance in our understanding of biological mechanisms and potential translational targets during the next-generation sequencing era than in paediatric brain tumours. The so-called omics revolution, enabled by high-throughput sequencing, has empowered large consortia and independent groups alike to make major genetic discoveries, from dominant-negative histone mutations and hijacking of distal enhancer elements, to new oncogenic gene fusions and aberrantly active gene expression. Epigenetic deregulation has also been revealed as a common theme across several tumour subtypes. This Review focuses on key findings that have been transforming the landscape of paediatric neuro-oncology research and how these results are opening new avenues towards potential therapeutic translation.
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000127228 650_7 $$2NLM Chemicals$$aNeoplasm Proteins
000127228 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b1$$udkfz
000127228 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b2$$eLast author$$udkfz
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