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@ARTICLE{Northcott:127228,
      author       = {P. A. Northcott$^*$ and S. Pfister$^*$ and D. Jones$^*$},
      title        = {{N}ext-generation (epi)genetic drivers of childhood brain
                      tumours and the outlook for targeted therapies.},
      journal      = {The lancet / Oncology},
      volume       = {16},
      number       = {6},
      issn         = {1470-2045},
      address      = {London},
      publisher    = {The Lancet Publ. Group},
      reportid     = {DKFZ-2017-03253},
      pages        = {e293 - e302},
      year         = {2015},
      abstract     = {Arguably, nowhere has there been a greater advance in our
                      understanding of biological mechanisms and potential
                      translational targets during the next-generation sequencing
                      era than in paediatric brain tumours. The so-called omics
                      revolution, enabled by high-throughput sequencing, has
                      empowered large consortia and independent groups alike to
                      make major genetic discoveries, from dominant-negative
                      histone mutations and hijacking of distal enhancer elements,
                      to new oncogenic gene fusions and aberrantly active gene
                      expression. Epigenetic deregulation has also been revealed
                      as a common theme across several tumour subtypes. This
                      Review focuses on key findings that have been transforming
                      the landscape of paediatric neuro-oncology research and how
                      these results are opening new avenues towards potential
                      therapeutic translation.},
      keywords     = {Neoplasm Proteins (NLM Chemicals)},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26065614},
      doi          = {10.1016/S1470-2045(14)71206-9},
      url          = {https://inrepo02.dkfz.de/record/127228},
}