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| 001 | 127228 | ||
| 005 | 20240228140912.0 | ||
| 024 | 7 | _ | |a 10.1016/S1470-2045(14)71206-9 |2 doi |
| 024 | 7 | _ | |a pmid:26065614 |2 pmid |
| 024 | 7 | _ | |a 1470-2045 |2 ISSN |
| 024 | 7 | _ | |a 1474-5488 |2 ISSN |
| 024 | 7 | _ | |a altmetric:4064981 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-03253 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Northcott, Paul A |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies. |
| 260 | _ | _ | |a London |c 2015 |b The Lancet Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1508838198_29226 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Arguably, nowhere has there been a greater advance in our understanding of biological mechanisms and potential translational targets during the next-generation sequencing era than in paediatric brain tumours. The so-called omics revolution, enabled by high-throughput sequencing, has empowered large consortia and independent groups alike to make major genetic discoveries, from dominant-negative histone mutations and hijacking of distal enhancer elements, to new oncogenic gene fusions and aberrantly active gene expression. Epigenetic deregulation has also been revealed as a common theme across several tumour subtypes. This Review focuses on key findings that have been transforming the landscape of paediatric neuro-oncology research and how these results are opening new avenues towards potential therapeutic translation. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Neoplasm Proteins |2 NLM Chemicals |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 1 |u dkfz |
| 700 | 1 | _ | |a Jones, David |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 2 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/S1470-2045(14)71206-9 |g Vol. 16, no. 6, p. e293 - e302 |0 PERI:(DE-600)2035574-9 |n 6 |p e293 - e302 |t The @lancet |v 16 |y 2015 |x 1470-2045 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:127228 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-HGF)0 |
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| 914 | 1 | _ | |y 2015 |
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| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b LANCET ONCOL : 2015 |
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| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
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| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l Pädiatrische Neuroonkologie |x 0 |
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| 980 | _ | _ | |a UNRESTRICTED |
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