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@ARTICLE{Pftze:127299,
      author       = {K. Pfütze$^*$ and A. Benner$^*$ and M. Hoffmeister$^*$ and
                      L. Jansen$^*$ and R. Yang$^*$ and H. Bläker and E.
                      Herpel$^*$ and A. Ulrich and C. M. Ulrich$^*$ and J.
                      Chang-Claude$^*$ and H. Brenner$^*$ and B. Burwinkel$^*$},
      title        = {{M}ethylation status at {HYAL}2 predicts overall and
                      progression-free survival of colon cancer patients under
                      5-{FU} chemotherapy.},
      journal      = {Genomics},
      volume       = {106},
      number       = {6},
      issn         = {0888-7543},
      address      = {San Diego, Calif.},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2017-03324},
      pages        = {348 - 354},
      year         = {2015},
      abstract     = {DNA methylation variations in gene promoter regions are
                      well documented tumor-specific alterations in human
                      malignancies including colon cancer, which may influence
                      tumor behavior and clinical outcome. As a subset of colon
                      cancer patients does not benefit from adjuvant chemotherapy,
                      predictive biomarkers are desirable. Here, we describe that
                      DNA methylation levels at CpG loci of
                      hyaluronoglucosaminidase 2 (HYLA2) could be used to identify
                      stage II and III colon cancer patients who are most likely
                      to benefit from 5-flourouracil (5-FU) chemotherapy with
                      respect to overall survival and progression-free survival.},
      keywords     = {Antimetabolites, Antineoplastic (NLM Chemicals) / Cell
                      Adhesion Molecules (NLM Chemicals) / GPI-Linked Proteins
                      (NLM Chemicals) / Hyal2 protein, human (NLM Chemicals) /
                      Hyaluronoglucosaminidase (NLM Chemicals) / Fluorouracil (NLM
                      Chemicals)},
      cin          = {G100 / C060 / C070 / G010 / G035 / C080 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)G100-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)C070-20160331 / I:(DE-He78)G010-20160331 /
                      I:(DE-He78)G035-20160331 / I:(DE-He78)C080-20160331 /
                      I:(DE-He78)G110-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26453961},
      doi          = {10.1016/j.ygeno.2015.10.002},
      url          = {https://inrepo02.dkfz.de/record/127299},
}