Journal Article

DKFZ-2017-03324

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Methylation status at HYAL2 predicts overall and progression-free survival of colon cancer patients under 5-FU chemotherapy.

Pfütze, K. (First author)DKFZ* ; Benner, A.DKFZ* ; Hoffmeister, M.DKFZ* ; Jansen, L.DKFZ* ; Yang, R.DKFZ* ; Bläker, H. ; Herpel, E.DKFZ* ; Ulrich, A. ; Ulrich, C. M.DKFZ* ; Chang-Claude, J.DKFZ* ; Brenner, H.DKFZ* ; Burwinkel, B. (Last author)DKFZ*

2015
Academic Press San Diego, Calif.

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Please use a persistent id in citations: doi:10.1016/j.ygeno.2015.10.002

Abstract: DNA methylation variations in gene promoter regions are well documented tumor-specific alterations in human malignancies including colon cancer, which may influence tumor behavior and clinical outcome. As a subset of colon cancer patients does not benefit from adjuvant chemotherapy, predictive biomarkers are desirable. Here, we describe that DNA methylation levels at CpG loci of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil (5-FU) chemotherapy with respect to overall survival and progression-free survival.

Keyword(s): Antimetabolites, Antineoplastic ; Cell Adhesion Molecules ; GPI-Linked Proteins ; Hyal2 protein, human ; Hyaluronoglucosaminidase ; Fluorouracil

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Contributing Institute(s):

1. Translationale Onkologie (G100)
2. Biostatistik (C060)
3. Klinische Epidemiologie und Alternsforschung (C070)
4. Geschäftsstelle (G010)
5. Tumor- und Serumbank (G035)
6. Molekulare Epidemiologie (C080)
7. Präventive Onkologie (G110)
8. DKTK Heidelberg (L101)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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