001     127299
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024 7 _ |a 10.1016/j.ygeno.2015.10.002
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100 1 _ |a Pfütze, Katrin
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245 _ _ |a Methylation status at HYAL2 predicts overall and progression-free survival of colon cancer patients under 5-FU chemotherapy.
260 _ _ |a San Diego, Calif.
|c 2015
|b Academic Press
336 7 _ |a article
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520 _ _ |a DNA methylation variations in gene promoter regions are well documented tumor-specific alterations in human malignancies including colon cancer, which may influence tumor behavior and clinical outcome. As a subset of colon cancer patients does not benefit from adjuvant chemotherapy, predictive biomarkers are desirable. Here, we describe that DNA methylation levels at CpG loci of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil (5-FU) chemotherapy with respect to overall survival and progression-free survival.
536 _ _ |a 313 - Cancer risk factors and prevention (POF3-313)
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650 _ 7 |a Antimetabolites, Antineoplastic
|2 NLM Chemicals
650 _ 7 |a Cell Adhesion Molecules
|2 NLM Chemicals
650 _ 7 |a GPI-Linked Proteins
|2 NLM Chemicals
650 _ 7 |a Hyal2 protein, human
|0 EC 3.2.1.25
|2 NLM Chemicals
650 _ 7 |a Hyaluronoglucosaminidase
|0 EC 3.2.1.35
|2 NLM Chemicals
650 _ 7 |a Fluorouracil
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700 1 _ |a Benner, Axel
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700 1 _ |a Hoffmeister, Michael
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700 1 _ |a Jansen, Lina
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700 1 _ |a Yang, Rongxi
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700 1 _ |a Bläker, Hendrik
|b 5
700 1 _ |a Herpel, Esther
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700 1 _ |a Ulrich, Alexis
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700 1 _ |a Ulrich, Cornelia M
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700 1 _ |a Chang-Claude, Jenny
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700 1 _ |a Brenner, Hermann
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700 1 _ |a Burwinkel, Barbara
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773 _ _ |a 10.1016/j.ygeno.2015.10.002
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