Home > Publications database > Methylation status at HYAL2 predicts overall and progression-free survival of colon cancer patients under 5-FU chemotherapy. > print |
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024 | 7 | _ | |a 10.1016/j.ygeno.2015.10.002 |2 doi |
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100 | 1 | _ | |a Pfütze, Katrin |0 P:(DE-He78)83906db1355a576371363a4b9f107d3d |b 0 |e First author |u dkfz |
245 | _ | _ | |a Methylation status at HYAL2 predicts overall and progression-free survival of colon cancer patients under 5-FU chemotherapy. |
260 | _ | _ | |a San Diego, Calif. |c 2015 |b Academic Press |
336 | 7 | _ | |a article |2 DRIVER |
336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521707934_2108 |2 PUB:(DE-HGF) |
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520 | _ | _ | |a DNA methylation variations in gene promoter regions are well documented tumor-specific alterations in human malignancies including colon cancer, which may influence tumor behavior and clinical outcome. As a subset of colon cancer patients does not benefit from adjuvant chemotherapy, predictive biomarkers are desirable. Here, we describe that DNA methylation levels at CpG loci of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil (5-FU) chemotherapy with respect to overall survival and progression-free survival. |
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650 | _ | 7 | |a Antimetabolites, Antineoplastic |2 NLM Chemicals |
650 | _ | 7 | |a Cell Adhesion Molecules |2 NLM Chemicals |
650 | _ | 7 | |a GPI-Linked Proteins |2 NLM Chemicals |
650 | _ | 7 | |a Hyal2 protein, human |0 EC 3.2.1.25 |2 NLM Chemicals |
650 | _ | 7 | |a Hyaluronoglucosaminidase |0 EC 3.2.1.35 |2 NLM Chemicals |
650 | _ | 7 | |a Fluorouracil |0 U3P01618RT |2 NLM Chemicals |
700 | 1 | _ | |a Benner, Axel |0 P:(DE-He78)e15dfa1260625c69d6690a197392a994 |b 1 |u dkfz |
700 | 1 | _ | |a Hoffmeister, Michael |0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f |b 2 |u dkfz |
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700 | 1 | _ | |a Yang, Rongxi |0 P:(DE-He78)dd35af1fb84ec0812fe4bdea97d2f291 |b 4 |u dkfz |
700 | 1 | _ | |a Bläker, Hendrik |b 5 |
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700 | 1 | _ | |a Ulrich, Alexis |b 7 |
700 | 1 | _ | |a Ulrich, Cornelia M |0 P:(DE-HGF)0 |b 8 |
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700 | 1 | _ | |a Burwinkel, Barbara |0 P:(DE-He78)15b7fd2bc02d5ef47a2fe2dd0140d2bf |b 11 |e Last author |u dkfz |
773 | _ | _ | |a 10.1016/j.ygeno.2015.10.002 |g Vol. 106, no. 6, p. 348 - 354 |0 PERI:(DE-600)1468023-3 |n 6 |p 348 - 354 |t Genomics |v 106 |y 2015 |x 0888-7543 |
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