Journal Article

DKFZ-2017-03346

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Synthesis and biological evaluation of 9-N-oxamyl sialosides as Siglec-7 ligands.

Prescher, H. ; Gütgemann, S. ; Frank, M.DKFZ* ; Kuhfeldt, E. ; Watzl, C. ; Brossmer, R.

2015
Elsevier Amsterdam [u.a.]

Abstract: Siglecs (sialic acid recognizing immunoglobulin like lectins) are a family of lectins with specificity for sialic acid containing carbohydrates. Synthetic sialic acid derivatives with high affinity proved useful to unravel the biological role of the ligand binding domain, although many of their functions in immunity remain unknown. Here we present design, synthesis, affinity evaluation and molecular modeling of novel 9-N-oxamoyl modified sialosides as Siglec-7 ligands.

Keyword(s): Lectins ; Ligands ; Neuraminic Acids ; N-Acetylneuraminic Acid

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Contributing Institute(s):

1. Molekulare Strukturanalyse (W160)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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