Journal Article

DKFZ-2017-03531

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain.

Selvaraj, D. ; Gangadharan, V. ; Michalski, C. W. ; Kurejova, M. ; Stösser, S. ; Srivastava, K.DKFZ* ; Schweizerhof, M. ; Waltenberger, J. ; Ferrara, N. ; Heppenstall, P. ; Shibuya, M. ; Augustin, H.DKFZ* ; Kuner, R.

2015
Cell Press Cambridge, Mass.

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Please use a persistent id in citations: doi:10.1016/j.ccell.2015.04.017

Abstract: Cancer pain is a debilitating disorder and a primary determinant of the poor quality of life. Here, we report a non-vascular role for ligands of the Vascular Endothelial Growth Factor (VEGF) family in cancer pain. Tumor-derived VEGF-A, PLGF-2, and VEGF-B augment pain sensitivity through selective activation of VEGF receptor 1 (VEGFR1) expressed in sensory neurons in human cancer and mouse models. Sensory-neuron-specific genetic deletion/silencing or local or systemic blockade of VEGFR1 prevented tumor-induced nerve remodeling and attenuated cancer pain in diverse mouse models in vivo. These findings identify a therapeutic potential for VEGFR1-modifying drugs in cancer pain and suggest a palliative effect for VEGF/VEGFR1-targeting anti-angiogenic tumor therapies.

Keyword(s): Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor Receptor-1

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Contributing Institute(s):

1. Vaskuläre Onkologie und Metastasierung (A190)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 20 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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