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000127706 1001_ $$aVicuña, Lucas$$b0
000127706 245__ $$aThe serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
000127706 260__ $$aNew York, NY$$bNature America Inc.$$c2015
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000127706 520__ $$aNeuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide unclear results owing to the differential expression of hundreds of genes across sham and nerve-injured groups, which can be difficult to validate, particularly with respect to the specificity of pain modulation. To circumvent this, we used two outbred lines of rats, which are genetically similar except for being genetically segregated as a result of selective breeding for differences in neuropathic pain hypersensitivity. SerpinA3N, a serine protease inhibitor, was upregulated in the dorsal root ganglia (DRG) after nerve injury, which was further validated for its mouse homolog. Mice lacking SerpinA3N developed more neuropathic mechanical allodynia than wild-type (WT) mice, and exogenous delivery of SerpinA3N attenuated mechanical allodynia in WT mice. T lymphocytes infiltrate the DRG after nerve injury and release leukocyte elastase (LE), which was inhibited by SerpinA3N derived from DRG neurons. Genetic loss of LE or exogenous application of a LE inhibitor (Sivelastat) in WT mice attenuated neuropathic mechanical allodynia. Overall, we reveal a novel and clinically relevant role for a member of the serpin superfamily and a leukocyte elastase and crosstalk between neurons and T cells in the modulation of neuropathic pain.
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000127706 650_7 $$2NLM Chemicals$$aAcute-Phase Proteins
000127706 650_7 $$2NLM Chemicals$$aEnzyme Inhibitors
000127706 650_7 $$2NLM Chemicals$$aSerpina3n protein, mouse
000127706 650_7 $$2NLM Chemicals$$aSerpina3n protein, rat
000127706 650_7 $$2NLM Chemicals$$aSerpins
000127706 650_7 $$0EC 3.4.21.37$$2NLM Chemicals$$aLeukocyte Elastase
000127706 7001_ $$aStrochlic, David E$$b1
000127706 7001_ $$aLatremoliere, Alban$$b2
000127706 7001_ $$00000-0002-9503-1402$$aBali, Kiran Kumar$$b3
000127706 7001_ $$aSimonetti, Manuela$$b4
000127706 7001_ $$aHusainie, Dewi$$b5
000127706 7001_ $$0P:(DE-He78)3c6157a315192b4a95e0138399b89da9$$aProkosch, Sandra$$b6$$udkfz
000127706 7001_ $$aRiva, Priscilla$$b7
000127706 7001_ $$aGriffin, Robert S$$b8
000127706 7001_ $$aNjoo, Christian$$b9
000127706 7001_ $$aGehrig, Stefanie$$b10
000127706 7001_ $$aMall, Marcus A$$b11
000127706 7001_ $$0P:(DE-He78)554abc2af2666cc3421cc0d7f6e7b6de$$aArnold, Bernd$$b12$$udkfz
000127706 7001_ $$00000-0001-8206-3301$$aDevor, Marshall$$b13
000127706 7001_ $$aWoolf, Clifford J$$b14
000127706 7001_ $$aLiberles, Stephen D$$b15
000127706 7001_ $$aCostigan, Michael$$b16
000127706 7001_ $$aKuner, Rohini$$b17
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