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@ARTICLE{Wang:127746,
      author       = {X. Wang and A. M. Dubuc and V. Ramaswamy and S. Mack and D.
                      M. A. Gendoo and M. Remke and X. Wu and L. Garzia and B. Luu
                      and F. Cavalli and J. Peacock and B. López and P. Skowron
                      and D. Zagzag and D. Lyden and C. Hoffman and Y.-J. Cho and
                      C. Eberhart and T. MacDonald and X.-N. Li and T. Van Meter
                      and P. A. Northcott$^*$ and B. Haibe-Kains and C. Hawkins
                      and J. T. Rutka and E. Bouffet and S. Pfister$^*$ and A.
                      Korshunov$^*$ and M. D. Taylor},
      title        = {{M}edulloblastoma subgroups remain stable across primary
                      and metastatic compartments.},
      journal      = {Acta neuropathologica},
      volume       = {129},
      number       = {3},
      issn         = {1432-0533},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2017-03769},
      pages        = {449 - 457},
      year         = {2015},
      abstract     = {Medulloblastoma comprises four distinct molecular variants
                      with distinct genetics, transcriptomes, and outcomes.
                      Subgroup affiliation has been previously shown to remain
                      stable at the time of recurrence, which likely reflects
                      their distinct cells of origin. However, a therapeutically
                      relevant question that remains unanswered is subgroup
                      stability in the metastatic compartment. We assembled a
                      cohort of 12-paired primary-metastatic tumors collected in
                      the MAGIC consortium, and established their molecular
                      subgroup affiliation by performing integrative gene
                      expression and DNA methylation analysis. Frozen tissues were
                      collected and profiled using Affymetrix gene expression
                      arrays and Illumina methylation arrays. Class prediction and
                      hierarchical clustering were performed using existing
                      published datasets. Our molecular analysis, using consensus
                      integrative genomic data, establishes the unequivocal
                      maintenance of molecular subgroup affiliation in metastatic
                      medulloblastoma. We further validated these findings by
                      interrogating a non-overlapping cohort of 19 pairs of
                      primary-metastatic tumors from the Burdenko Neurosurgical
                      Institute using an orthogonal technique of
                      immunohistochemical staining. This investigation represents
                      the largest reported primary-metastatic paired cohort
                      profiled to date and provides a unique opportunity to
                      evaluate subgroup-specific molecular aberrations within the
                      metastatic compartment. Our findings further support the
                      hypothesis that medulloblastoma subgroups arise from
                      distinct cells of origin, which are carried forward from
                      ontogeny to oncology.},
      cin          = {B062 / G380 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)G380-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25689980},
      pmc          = {pmc:PMC4333718},
      doi          = {10.1007/s00401-015-1389-0},
      url          = {https://inrepo02.dkfz.de/record/127746},
}