guest ::
| Home > Publications database > Medulloblastoma subgroups remain stable across primary and metastatic compartments. > print |
| Home > Publications database > Medulloblastoma subgroups remain stable across primary and metastatic compartments. > print |
| 001 | 127746 | ||
| 005 | 20240228140947.0 | ||
| 024 | 7 | _ | |a 10.1007/s00401-015-1389-0 |2 doi |
| 024 | 7 | _ | |a pmid:25689980 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4333718 |2 pmc |
| 024 | 7 | _ | |a 0001-6322 |2 ISSN |
| 024 | 7 | _ | |a 1432-0533 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2017-03769 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Wang, Xin |b 0 |
| 245 | _ | _ | |a Medulloblastoma subgroups remain stable across primary and metastatic compartments. |
| 260 | _ | _ | |a Berlin |c 2015 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1508922709_22424 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Medulloblastoma comprises four distinct molecular variants with distinct genetics, transcriptomes, and outcomes. Subgroup affiliation has been previously shown to remain stable at the time of recurrence, which likely reflects their distinct cells of origin. However, a therapeutically relevant question that remains unanswered is subgroup stability in the metastatic compartment. We assembled a cohort of 12-paired primary-metastatic tumors collected in the MAGIC consortium, and established their molecular subgroup affiliation by performing integrative gene expression and DNA methylation analysis. Frozen tissues were collected and profiled using Affymetrix gene expression arrays and Illumina methylation arrays. Class prediction and hierarchical clustering were performed using existing published datasets. Our molecular analysis, using consensus integrative genomic data, establishes the unequivocal maintenance of molecular subgroup affiliation in metastatic medulloblastoma. We further validated these findings by interrogating a non-overlapping cohort of 19 pairs of primary-metastatic tumors from the Burdenko Neurosurgical Institute using an orthogonal technique of immunohistochemical staining. This investigation represents the largest reported primary-metastatic paired cohort profiled to date and provides a unique opportunity to evaluate subgroup-specific molecular aberrations within the metastatic compartment. Our findings further support the hypothesis that medulloblastoma subgroups arise from distinct cells of origin, which are carried forward from ontogeny to oncology. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Dubuc, Adrian M |b 1 |
| 700 | 1 | _ | |a Ramaswamy, Vijay |b 2 |
| 700 | 1 | _ | |a Mack, Stephen |b 3 |
| 700 | 1 | _ | |a Gendoo, Deena M A |b 4 |
| 700 | 1 | _ | |a Remke, Marc |b 5 |
| 700 | 1 | _ | |a Wu, Xiaochong |b 6 |
| 700 | 1 | _ | |a Garzia, Livia |b 7 |
| 700 | 1 | _ | |a Luu, Betty |b 8 |
| 700 | 1 | _ | |a Cavalli, Florence |b 9 |
| 700 | 1 | _ | |a Peacock, John |b 10 |
| 700 | 1 | _ | |a López, Borja |b 11 |
| 700 | 1 | _ | |a Skowron, Patryk |b 12 |
| 700 | 1 | _ | |a Zagzag, David |b 13 |
| 700 | 1 | _ | |a Lyden, David |b 14 |
| 700 | 1 | _ | |a Hoffman, Caitlin |b 15 |
| 700 | 1 | _ | |a Cho, Yoon-Jae |b 16 |
| 700 | 1 | _ | |a Eberhart, Charles |b 17 |
| 700 | 1 | _ | |a MacDonald, Tobey |b 18 |
| 700 | 1 | _ | |a Li, Xiao-Nan |b 19 |
| 700 | 1 | _ | |a Van Meter, Timothy |b 20 |
| 700 | 1 | _ | |a Northcott, Paul A |0 P:(DE-HGF)0 |b 21 |
| 700 | 1 | _ | |a Haibe-Kains, Benjamin |b 22 |
| 700 | 1 | _ | |a Hawkins, Cynthia |b 23 |
| 700 | 1 | _ | |a Rutka, James T |b 24 |
| 700 | 1 | _ | |a Bouffet, Eric |b 25 |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 26 |u dkfz |
| 700 | 1 | _ | |a Korshunov, Andrey |0 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |b 27 |u dkfz |
| 700 | 1 | _ | |a Taylor, Michael D |b 28 |
| 773 | _ | _ | |a 10.1007/s00401-015-1389-0 |g Vol. 129, no. 3, p. 449 - 457 |0 PERI:(DE-600)1458410-4 |n 3 |p 449 - 457 |t Acta neuropathologica |v 129 |y 2015 |x 1432-0533 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:127746 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 21 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 26 |6 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 27 |6 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2015 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ACTA NEUROPATHOL : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b ACTA NEUROPATHOL : 2015 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l Pädiatrische Neuroonkologie |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)G380-20160331 |k G380 |l KKE Neuropathologie |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)L101-20160331 |k L101 |l DKTK Heidelberg |x 2 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)G380-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L101-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|