Journal Article

DKFZ-2017-03889

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png FUCCI sensors: powerful new tools for analysis of cell proliferation.

Zielke, N. (First author)DKFZ* ; Edgar, B. (Last author)DKFZ*

2015
Wiley-Blackwell Malden, MA

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Please use a persistent id in citations: doi:10.1002/wdev.189

Abstract: Visualizing the cell cycle behavior of individual cells within living organisms can facilitate the understanding of developmental processes such as pattern formation, morphogenesis, cell differentiation, growth, cell migration, and cell death. Fluorescence Ubiquitin Cell Cycle Indicator (FUCCI) technology offers an accurate, versatile, and universally applicable means of achieving this end. In recent years, the FUCCI system has been adapted to several model systems including flies, fish, mice, and plants, making this technology available to a wide range of researchers for studies of diverse biological problems. Moreover, a broad range of FUCCI-expressing cell lines originating from diverse cell types have been generated, hence enabling the design of advanced studies that combine in vivo experiments and cell-based methods such as high-content screening. Although only a short time has passed since its introduction, the FUCCI technology has already provided fundamental insight into how cells establish quiescence and how G1 phase length impacts the balance between pluripotency and stem cell differentiation. Further discoveries using the FUCCI technology are sure to come.

Keyword(s): Ubiquitin

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Contributing Institute(s):

1. Zellwachstum und Proliferation (A220)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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