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| Home > Publications database > Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma. > print |
| 001 | 127948 | ||
| 005 | 20240228135038.0 | ||
| 024 | 7 | _ | |a 10.1038/leu.2014.75 |2 doi |
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| 024 | 7 | _ | |a 1476-5551 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2017-03970 |
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| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Merz, M. |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma. |
| 260 | _ | _ | |a Basingstoke |c 2014 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521813901_5360 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Previous studies demonstrated the relevance of focal lesions (FL) in whole-body magnetic resonance imaging (wb-MRI) at the initial workup of patients with smoldering multiple myeloma (SMM). The aim of this study was to assess the effects of longitudinal wb-MRIs on progression into multiple myeloma (MM). Sixty-three patients with SMM were analyzed who received at least two wb-MRIs for follow-up before progression into MM. Radiological progressive disease (MRI-PD) was defined as detection of new FL or increase in diameter of existing FL and a novel or progressive diffuse infiltration. Radiological stable disease (MRI-SD) was defined by no change compared with the prior MRI. Patients were followed-up every 3-6 months, including a serological and clinical evaluation. One Hundred and eighty-two wb-MRIs were analyzed. MRI-PD occurred in 31 patients (49%), and 25 (40%) patients developed MM. MRI-PD was highly significantly associated with progression into MM, regardless of findings at the initial MRI. In multivariate analysis, MRI-PD remained a risk factor, independent of relevant baseline parameters like serum monoclonal protein or ⩾95% aberrant plasma cells in the bone marrow. Patients with MRI-SD had no higher risk of progression, even when FL were present at the initial MRI. Therefore, MRI is suitable for the follow-up of patients with SMM. |
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| 700 | 1 | _ | |a Hielscher, T. |0 P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f |b 1 |u dkfz |
| 700 | 1 | _ | |a Wagner, B. |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Sauer, S. |b 3 |
| 700 | 1 | _ | |a Shah, S. |b 4 |
| 700 | 1 | _ | |a Raab, M. S. |0 P:(DE-He78)1cb537e833afd985097ccfaddffb2ef3 |b 5 |u dkfz |
| 700 | 1 | _ | |a Jauch, A. |b 6 |
| 700 | 1 | _ | |a Neben, K. |b 7 |
| 700 | 1 | _ | |a Hose, D. |b 8 |
| 700 | 1 | _ | |a Egerer, G. |b 9 |
| 700 | 1 | _ | |a Weber, M. A. |b 10 |
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| 700 | 1 | _ | |a Goldschmidt, H. |b 12 |
| 700 | 1 | _ | |a Hillengass, Jens |0 P:(DE-He78)7ccc574e713526d2a22d7acb9b2248c5 |b 13 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1038/leu.2014.75 |g Vol. 28, no. 9, p. 1902 - 1908 |0 PERI:(DE-600)2008023-2 |n 9 |p 1902 - 1908 |t Leukemia |v 28 |y 2014 |x 1476-5551 |
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