Journal Article

DKFZ-2017-03970

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma.

Merz, M. (First author)DKFZ* ; Hielscher, T.DKFZ* ; Wagner, B.DKFZ* ; Sauer, S. ; Shah, S. ; Raab, M. S.DKFZ* ; Jauch, A. ; Neben, K. ; Hose, D. ; Egerer, G. ; Weber, M. A. ; Delorme, S.DKFZ* ; Goldschmidt, H. ; Hillengass, J. (Last author)DKFZ*

2014
Nature Publ. Group Basingstoke

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Please use a persistent id in citations: doi:10.1038/leu.2014.75

Abstract: Previous studies demonstrated the relevance of focal lesions (FL) in whole-body magnetic resonance imaging (wb-MRI) at the initial workup of patients with smoldering multiple myeloma (SMM). The aim of this study was to assess the effects of longitudinal wb-MRIs on progression into multiple myeloma (MM). Sixty-three patients with SMM were analyzed who received at least two wb-MRIs for follow-up before progression into MM. Radiological progressive disease (MRI-PD) was defined as detection of new FL or increase in diameter of existing FL and a novel or progressive diffuse infiltration. Radiological stable disease (MRI-SD) was defined by no change compared with the prior MRI. Patients were followed-up every 3-6 months, including a serological and clinical evaluation. One Hundred and eighty-two wb-MRIs were analyzed. MRI-PD occurred in 31 patients (49%), and 25 (40%) patients developed MM. MRI-PD was highly significantly associated with progression into MM, regardless of findings at the initial MRI. In multivariate analysis, MRI-PD remained a risk factor, independent of relevant baseline parameters like serum monoclonal protein or ⩾95% aberrant plasma cells in the bone marrow. Patients with MRI-SD had no higher risk of progression, even when FL were present at the initial MRI. Therefore, MRI is suitable for the follow-up of patients with SMM.

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Contributing Institute(s):

1. Radiologie (E010)
2. Biostatistik (C060)
3. Hämatoonkologische Bildgebung (E013)
4. KKE Molekulare Hämatologie/Onkologie (G330)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2014

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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