TY  - JOUR
AU  - Sturm, Dominik
AU  - Bender, Sebastian
AU  - Jones, David
AU  - Lichter, Peter
AU  - Grill, Jacques
AU  - Becher, Oren
AU  - Hawkins, Cynthia
AU  - Majewski, Jacek
AU  - Jones, Chris
AU  - Costello, Joseph F
AU  - Iavarone, Antonio
AU  - Aldape, Kenneth
AU  - Brennan, Cameron W
AU  - Jabado, Nada
AU  - Pfister, Stefan
TI  - Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.
JO  - Nature reviews / Cancer
VL  - 14
IS  - 2
SN  - 1474-1768
CY  - London [u.a.]
PB  - Nature Publ. Group
M1  - DKFZ-2017-04416
SP  - 92 - 107
PY  - 2014
AB  - We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.
LB  - PUB:(DE-HGF)16
C6  - pmid:24457416
C2  - pmc:PMC4003223
DO  - DOI:10.1038/nrc3655
UR  - https://inrepo02.dkfz.de/record/128400
ER  -