Journal Article

DKFZ-2017-04416

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.

Sturm, D. (First author)DKFZ* ; Bender, S.DKFZ* ; Jones, D.DKFZ* ; Lichter, P.DKFZ* ; Grill, J. ; Becher, O. ; Hawkins, C. ; Majewski, J. ; Jones, C. ; Costello, J. F. ; Iavarone, A. ; Aldape, K. ; Brennan, C. W. ; Jabado, N. ; Pfister, S. (Last author)DKFZ*

2014
Nature Publ. Group London [u.a.]

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Please use a persistent id in citations: doi:10.1038/nrc3655

Abstract: We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.

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Contributing Institute(s):

1. Pädiatrische Neuroonkologie (B062)
2. Molekulare Genetik (B060)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2014

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 30 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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