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@ARTICLE{Sturm:128400,
      author       = {D. Sturm$^*$ and S. Bender$^*$ and D. Jones$^*$ and P.
                      Lichter$^*$ and J. Grill and O. Becher and C. Hawkins and J.
                      Majewski and C. Jones and J. F. Costello and A. Iavarone and
                      K. Aldape and C. W. Brennan and N. Jabado and S.
                      Pfister$^*$},
      title        = {{P}aediatric and adult glioblastoma: multiform (epi)genomic
                      culprits emerge.},
      journal      = {Nature reviews / Cancer},
      volume       = {14},
      number       = {2},
      issn         = {1474-1768},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2017-04416},
      pages        = {92 - 107},
      year         = {2014},
      abstract     = {We have extended our understanding of the molecular biology
                      that underlies adult glioblastoma over many years. By
                      contrast, high-grade gliomas in children and adolescents
                      have remained a relatively under-investigated disease. The
                      latest large-scale genomic and epigenomic profiling studies
                      have yielded an unprecedented abundance of novel data and
                      provided deeper insights into gliomagenesis across all age
                      groups, which has highlighted key distinctions but also some
                      commonalities. As we are on the verge of dissecting
                      glioblastomas into meaningful biological subgroups, this
                      Review summarizes the hallmark genetic alterations that are
                      associated with distinct epigenetic features and patient
                      characteristics in both paediatric and adult disease, and
                      examines the complex interplay between the glioblastoma
                      genome and epigenome.},
      cin          = {B062 / B060},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B060-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24457416},
      pmc          = {pmc:PMC4003223},
      doi          = {10.1038/nrc3655},
      url          = {https://inrepo02.dkfz.de/record/128400},
}