TY  - JOUR
AU  - Ugarte-Uribe, Begoña
AU  - García-Sáez, Ana J
TI  - Membranes in motion: mitochondrial dynamics and their role in apoptosis.
JO  - Biological chemistry
VL  - 395
IS  - 3
SN  - 1437-4315
CY  - Berlin [u.a.]
PB  - de Gruyter
M1  - DKFZ-2017-04465
SP  - 297-311
PY  - 2014
AB  - Mitochondrial dynamics is crucial for cell survival, development and homeostasis and impairment of these functions leads to neurologic disorders and metabolic diseases. The key components of mitochondrial dynamics have been identified. Mitofusins and OPA1 mediate mitochondrial fusion, whereas Drp1 is responsible for mitochondrial fission. In addition, an interplay between the proteins of the mitochondrial fission/fusion machinery and the Bcl-2 proteins, essential mediators in apoptosis, has been also described. Here, we review the molecular mechanisms regarding mitochondrial dynamics together with their role in apoptosis.
LB  - PUB:(DE-HGF)16
C6  - pmid:24184992
DO  - DOI:10.1515/hsz-2013-0234
UR  - https://inrepo02.dkfz.de/record/128449
ER  -