Journal Article

DKFZ-2017-04465

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Membranes in motion: mitochondrial dynamics and their role in apoptosis.

Ugarte-Uribe, B. ; García-Sáez, A. J. (Last author)DKFZ*

2014
de Gruyter Berlin [u.a.]

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Please use a persistent id in citations: doi:10.1515/hsz-2013-0234

Abstract: Mitochondrial dynamics is crucial for cell survival, development and homeostasis and impairment of these functions leads to neurologic disorders and metabolic diseases. The key components of mitochondrial dynamics have been identified. Mitofusins and OPA1 mediate mitochondrial fusion, whereas Drp1 is responsible for mitochondrial fission. In addition, an interplay between the proteins of the mitochondrial fission/fusion machinery and the Bcl-2 proteins, essential mediators in apoptosis, has been also described. Here, we review the molecular mechanisms regarding mitochondrial dynamics together with their role in apoptosis.

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Contributing Institute(s):

1. Membranbiophysik (B160)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2014

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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