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000128621 1001_ $$0P:(DE-He78)26712fbb7710e2e6ea9de830306ce125$$aEngeland, Christine$$b0$$eFirst author$$udkfz
000128621 245__ $$aA Tupaia paramyxovirus vector system for targeting and transgene expression.
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000128621 520__ $$aViruses from the diverse family of Paramyxoviridae include important pathogens and are applied in gene therapy and for cancer treatment. The Tupaia paramyxovirus (TPMV), isolated from the kidney of a tree shrew, does not infect human cells and neutralizing antibodies against other Paramyxoviridae do not cross-react with TPMV. Here, we present a vector system for de novo generation of infectious TPMV that allows for insertion of additional genes as well as targeting using antibody single-chain variable fragments. We show that the recombinant TPMV specifically infect cells expressing the targeted receptor and replicate in human cells. This vector system provides a valuable tool for both basic research and therapeutic applications.
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000128621 7001_ $$0P:(DE-HGF)0$$aBossow, Sascha$$b1
000128621 7001_ $$aHudacek, Andrew W$$b2
000128621 7001_ $$0P:(DE-He78)25e88e7894cbce24806666301288f7e5$$aHoyler, Birgit$$b3$$udkfz
000128621 7001_ $$0P:(DE-He78)27662eaafa2d5c10561c088d1ff527ed$$aFörster, Judith$$b4$$udkfz
000128621 7001_ $$0P:(DE-He78)3394ee8077921694b3249e0a5dcf355e$$aVeinalde, Rūta$$b5$$udkfz
000128621 7001_ $$0P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1$$aJäger, Dirk$$b6$$udkfz
000128621 7001_ $$aCattaneo, Roberto$$b7
000128621 7001_ $$0P:(DE-He78)833f90e2abdd29594ad5c4f08600f191$$aUngerechts, Guy$$b8$$udkfz
000128621 7001_ $$aSpringfeld, Christoph$$b9
000128621 773__ $$0PERI:(DE-600)2007065-2$$a10.1099/jgv.0.000887$$gVol. 98, no. 9, p. 2248 - 2257$$n9$$p2248 - 2257$$tJournal of general virology$$v98$$x1465-2099$$y2017
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