Journal Article

DKFZ-2017-04637

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A Tupaia paramyxovirus vector system for targeting and transgene expression.

Engeland, C. (First author)DKFZ* ; Bossow, S.DKFZ* ; Hudacek, A. W. ; Hoyler, B.DKFZ* ; Förster, J.DKFZ* ; Veinalde, R.DKFZ* ; Jäger, D.DKFZ* ; Cattaneo, R. ; Ungerechts, G.DKFZ* ; Springfeld, C.

2017
Soc. Reading

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Please use a persistent id in citations: doi:10.1099/jgv.0.000887

Abstract: Viruses from the diverse family of Paramyxoviridae include important pathogens and are applied in gene therapy and for cancer treatment. The Tupaia paramyxovirus (TPMV), isolated from the kidney of a tree shrew, does not infect human cells and neutralizing antibodies against other Paramyxoviridae do not cross-react with TPMV. Here, we present a vector system for de novo generation of infectious TPMV that allows for insertion of additional genes as well as targeting using antibody single-chain variable fragments. We show that the recombinant TPMV specifically infect cells expressing the targeted receptor and replicate in human cells. This vector system provides a valuable tool for both basic research and therapeutic applications.

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Contributing Institute(s):

1. Translationale Onkologie (G100)
2. Geschäftsstelle (G010)

Research Program(s):

1. 317 - Translational cancer research (POF3-317) (POF3-317)

Appears in the scientific report 2017

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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