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| 001 | 128621 | ||
| 005 | 20240228145540.0 | ||
| 024 | 7 | _ | |a 10.1099/jgv.0.000887 |2 doi |
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| 024 | 7 | _ | |a 0022-1317 |2 ISSN |
| 024 | 7 | _ | |a 1465-2099 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2017-04637 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Engeland, Christine |0 P:(DE-He78)26712fbb7710e2e6ea9de830306ce125 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a A Tupaia paramyxovirus vector system for targeting and transgene expression. |
| 260 | _ | _ | |a Reading |c 2017 |b Soc. |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Viruses from the diverse family of Paramyxoviridae include important pathogens and are applied in gene therapy and for cancer treatment. The Tupaia paramyxovirus (TPMV), isolated from the kidney of a tree shrew, does not infect human cells and neutralizing antibodies against other Paramyxoviridae do not cross-react with TPMV. Here, we present a vector system for de novo generation of infectious TPMV that allows for insertion of additional genes as well as targeting using antibody single-chain variable fragments. We show that the recombinant TPMV specifically infect cells expressing the targeted receptor and replicate in human cells. This vector system provides a valuable tool for both basic research and therapeutic applications. |
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| 700 | 1 | _ | |a Bossow, Sascha |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Hudacek, Andrew W |b 2 |
| 700 | 1 | _ | |a Hoyler, Birgit |0 P:(DE-He78)25e88e7894cbce24806666301288f7e5 |b 3 |u dkfz |
| 700 | 1 | _ | |a Förster, Judith |0 P:(DE-He78)27662eaafa2d5c10561c088d1ff527ed |b 4 |u dkfz |
| 700 | 1 | _ | |a Veinalde, Rūta |0 P:(DE-He78)3394ee8077921694b3249e0a5dcf355e |b 5 |u dkfz |
| 700 | 1 | _ | |a Jäger, Dirk |0 P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1 |b 6 |u dkfz |
| 700 | 1 | _ | |a Cattaneo, Roberto |b 7 |
| 700 | 1 | _ | |a Ungerechts, Guy |0 P:(DE-He78)833f90e2abdd29594ad5c4f08600f191 |b 8 |u dkfz |
| 700 | 1 | _ | |a Springfeld, Christoph |b 9 |
| 773 | _ | _ | |a 10.1099/jgv.0.000887 |g Vol. 98, no. 9, p. 2248 - 2257 |0 PERI:(DE-600)2007065-2 |n 9 |p 2248 - 2257 |t Journal of general virology |v 98 |y 2017 |x 1465-2099 |
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