TY  - JOUR
AU  - Feng, Weijun
AU  - Shao, Chunxuan
AU  - Liu, Hai-Kun
TI  - Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and Disease.
JO  - Frontiers in molecular neuroscience
VL  - 10
SN  - 1662-5099
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DKFZ-2017-04638
SP  - 309
PY  - 2017
N1  - DKFZ-ZMBH-Allianz
AB  - CHD7 (Chromo-Helicase-DNA binding protein 7) protein is an ATP-dependent chromatin remodeler. Heterozygous mutation of the CHD7 gene causes a severe congenital disease known as CHARGE syndrome. Most CHARGE syndrome patients have brain structural anomalies, implicating an important role of CHD7 during brain development. In this review, we summarize studies dissecting developmental functions of CHD7 in the brain and discuss pathogenic mechanisms behind neurodevelopmental defects caused by mutation of CHD7. As we discussed, CHD7 protein exhibits a remarkably specific and dynamic expression pattern in the brain. Studies in human and animal models have revealed that CHD7 is involved in multiple developmental lineages and processes in the brain. Mechanistically, CHD7 is essential for neural differentiation due to its transcriptional regulation in progenitor cells.
LB  - PUB:(DE-HGF)16
C6  - pmid:29033785
C2  - pmc:PMC5625114
DO  - DOI:10.3389/fnmol.2017.00309
UR  - https://inrepo02.dkfz.de/record/128622
ER  -