Journal Article (Review Article)

DKFZ-2017-04638

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and Disease.

Feng, W. (First author)DKFZ* ; Shao, C.DKFZ* ; Liu, H.-K. (Last author)DKFZ*

2017
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fnmol.2017.00309

Abstract: CHD7 (Chromo-Helicase-DNA binding protein 7) protein is an ATP-dependent chromatin remodeler. Heterozygous mutation of the CHD7 gene causes a severe congenital disease known as CHARGE syndrome. Most CHARGE syndrome patients have brain structural anomalies, implicating an important role of CHD7 during brain development. In this review, we summarize studies dissecting developmental functions of CHD7 in the brain and discuss pathogenic mechanisms behind neurodevelopmental defects caused by mutation of CHD7. As we discussed, CHD7 protein exhibits a remarkably specific and dynamic expression pattern in the brain. Studies in human and animal models have revealed that CHD7 is involved in multiple developmental lineages and processes in the brain. Mechanistically, CHD7 is essential for neural differentiation due to its transcriptional regulation in progenitor cells.

Note: DKFZ-ZMBH-Allianz

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Contributing Institute(s):

1. Molekulare Neurogenetik (A240)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2017

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Database coverage:
; ; ; BIOSIS Previews ; DOAJ Seal ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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