Journal Article

DKFZ-2017-05046

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.

Lesina, M. ; Wörmann, S. M. ; Morton, J. ; Diakopoulos, K. N. ; Korneeva, O. ; Wimmer, M. ; Einwächter, H. ; Sperveslage, J. ; Demir, I. E. ; Kehl, T.DKFZ* ; Saur, D. ; Sipos, B. ; Heikenwälder, M.DKFZ* ; Steiner, J. M. ; Wang, T. C. ; Sansom, O. J. ; Schmid, R. M. ; Algül, H.

2016
ASCJ Ann Arbor, Mich.

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Please use a persistent id in citations: doi:10.1172/JCI86477

Abstract: Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here, we have determined that nuclear RelA reinforces OIS to inhibit carcinogenesis in the Kras mouse model of PDAC. Inactivation of RelA accelerated pancreatic lesion formation in Kras mice by abrogating the senescence-associated secretory phenotype (SASP) gene transcription signature. Using genetic and pharmacological tools, we determined that RelA activation promotes OIS via elevation of the SASP factor CXCL1 (also known as KC), which activates CXCR2, during pancreatic carcinogenesis. In Kras mice, pancreas-specific inactivation of CXCR2 prevented OIS and was correlated with increased tumor proliferation and decreased survival. Moreover, reductions in CXCR2 levels were associated with advanced neoplastic lesions in tissue from human pancreatic specimens. Genetically disabling OIS in Kras mice caused RelA to promote tumor proliferation, suggesting a dual role for RelA signaling in pancreatic carcinogenesis. Taken together, our data suggest a pivotal role for RelA in regulating OIS in preneoplastic lesions and implicate the RelA/CXCL1/CXCR2 axis as an essential mechanism of tumor surveillance in PDAC.

Keyword(s): Chemokine CXCL1 ; Cxcl1 protein, mouse ; RNA, Messenger ; Receptors, Interleukin-8B ; Rela protein, mouse ; Transcription Factor RelA ; ras Proteins

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Contributing Institute(s):

1. Biologische Sicherheit (V155)
2. Chronische Entzündung und Krebs (F180)

Research Program(s):

1. 316 - Infections and cancer (POF3-316) (POF3-316)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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